2.1.1.56	malfunction	mutation defective in N-7 methylation but not 2-O'-methylation is lethal for DNV replication	721100	
2.1.1.56	malfunction	significant loss of RNA polymerase II gene occupancy is observed on enzyme suppression. Enzyme suppression inhibits transcriptional markers including histone H2BK120 ubiquitination, H3K4 and H3K36 methylation, RNA polymerase II C-terminal domain S5 and S2 phosphorylation, and PAFc recruitment	756401	
2.1.1.56	malfunction	when cellular enzyme activity is experimentally reduced by 50%, the proliferation rate of nontransformed mammary epithelial cells is unchanged, whereas a subset of breast cancer cell lines exhibit reduced proliferation and increased apoptosis	757896	
2.1.1.56	metabolism	the enzyme in complex with RNMT-activating miniprotein catalyzes the formation of a N7-methylated guanosine cap structure on the 5' end of nascent RNA polymerase II transcripts. The mRNA cap protects the primary transcript from exonucleases and recruits cap binding complexes that mediate RNA processing, export and translation	757862	
2.1.1.56	physiological function	mRNA guanosine cap by RNA guanine-7-methyltransferase is rate-limiting for cellular cap-methyltransferase activity, and enhancing this activity promotes cyclin D1 expression and cell formation	706020	
2.1.1.56	physiological function	N7 cap methylation is essential for viral replication	705423	
2.1.1.56	physiological function	the enzyme promotes RNA polymerase II-dependent transcription independent of mRNA capping and translation	756401