2.1.1.198 malfunction enzyme deletion affects efficiency of non-AUG initiation and the fidelity of translation -, 735241 2.1.1.198 malfunction strain DELTAyraL produces monomethylated cytosine1402 instead of dimethylated C1402 produced by the wild-type enzyme 705980 2.1.1.198 physiological function both the 2'-O-methylation (catalyzed by RsmI) and N4-methylation of C1402 (catalyzed by RsmH) are needed for efficient initiation at the UUG and GUG codon. m4Cm1402 in the 16S rRNA modulates the accuracy of P-site function. The modification is needed for efficient translation initiation at the UUG and GUG codons 705980