1.2.1.61	metabolism	enzyme is part of the degradation pathway of 4-nitrophenol which is a priority environmental pollutant	-, 719179	
1.2.1.61	metabolism	HqdC gene is part of a gene cluster associated with hydroquinone degradation into 3-oxoadipate	-, 724063	
1.2.1.61	additional information	highly conserved residues C281 and E247 are identified to be critical for its catalytic activity, and flexible docking studies of the enzyme-substrate system predict the interactions between PnpE and its substrate 4-hydroxymuconic semialdehyde, flexible docking of substrate to PnpE, molecular docking analysis, overview	742206	
1.2.1.61	physiological function	the pnpE-encoded enzyme gamma-hydroxymuconic semialdehyde dehydrogenase catalyzes the reduction of 4-hydroxymuconic semialdehyde to maleylacetate in Pseudomonas sp. strain WBC-3, playing a key role in the catabolism of toxic para-nitrophenol to Krebs cycle intermediates	742206