1.14.99.38	malfunction	decitabine-induced hypomethylation of the cholesterol 25-hydroxylase gene is responsible for cell death of myelodysplasia/leukemia cells	746440	
1.14.99.38	malfunction	loss of function of Ch25h leads to susceptibility to viral infections in vitro	727611	
1.14.99.38	malfunction	mice with a disruption in the cholesterol 25-hydroxylase gene regulate cholesterol metabolism normally. Ch25h-/- mice have higher levels of mRNAs coding for immunoglobulin A and immunoglobulin J. Disruption in the Cyp7b1 gene leads to significantly increased levels of 25-hydroxycholesterol in the circulation, and to significantly lower levels of IgA compared to wild-type mice	727109	
1.14.99.38	malfunction	patients with hereditary spastic paresis, a rare inherited disease with mutations in the CYP7B1 gene, have highly elevated levels of 25- and 27-hydroxycholesterol but normal levels of cholesterol and bile acids	727109	
1.14.99.38	additional information	25-hydroxycholesterol does not stimulate the sPLA2-IIA promoter in the mouse Schwann cell line MSC80	727109	
1.14.99.38	additional information	Ch25h expression is controlled primarily by type I IFN signaling, type1 IFN-mediated Ch25h expression is IFNR-dependent, overview	-, 715833	
1.14.99.38	additional information	the high concentrations of vitamin D3 metabolites required for upregulation of the cholesterol 25-hydroxylase gene makes it unlikely that these metabolites are important regulators of cholesterol 25-hydroxylase in vivo	727109	
1.14.99.38	physiological function	adenovirus-mediated enzyme overexpression in mice improves glucose tolerance and insulin sensitivity and lowers the homeostatic model assessment for insulin resistance score	745450	
1.14.99.38	physiological function	cholesterol 25-hydroxylase acts as a host restriction factor on pseudorabies virus replication	745479	
1.14.99.38	physiological function	cholesterol 25-hydroxylase inhibits porcine reproductive and respiratory syndrome virus replication	745658