1.13.11.54	metabolism	the enzyme plays an important role in ethylene synthesis pathway	764775	
1.13.11.54	additional information	Fe2+-dependent acireductone dioxygenase passes through an additional split dioxygen intermediate and then proceeds through an epoxy-like transition state with a small activation energy to the two products, crystal structure analysis, structure modeling and molecular simulations of the Fe2+ and Ni2+ enzyme, cf. 1.13.11.53, QM-DMD domain, overview. The ability of Fe2+-dependent acireductone dioxygenase to stabilize an additional intermediate and thus produce the two products is due to the RedOx flexibility of the Fe2+ as compared to the more electron-rich Ni2+	725214	
1.13.11.54	additional information	identification of potential effectors in the Arabidopsis thaliana G protein beta signaling pathway by an activation tagging approach to randomly create dominant suppressors of agb1-2, overview. Homology modeling of acireductone dioxygenase 1, overview	-, 725438	
1.13.11.54	physiological function	either facilitates recycling of methionine in living cells or exits this recycling pathway. Fe2+-dependent acireductone dioxygenase produces the 2-oxo acid precursor of methionine and formate	725214	
1.13.11.54	physiological function	enzyme overexpression improves submergence, drought, and salt tolerances of seedling through the enhancement of ethylene synthesis in rice	764775	
1.13.11.54	physiological function	isoform ARD4 regulates the ethylene and carotenoid signaling pathway, increases ethylene and carotenoid concentrations, and accelerates fruit ripening. Furthermore, ARD4 increases the antioxidative ability and cold hardiness in tomato	764909	
1.13.11.54	physiological function	matrix metalloproteinase MT1-MMP physically interacts with claudin-1 and acireductone dioxygenase 1, both associated with hepatitis C virus cell entry	743184	
1.13.11.54	physiological function	one function of acireductone dioxygenases is to operate in the methionine salvage pathway. Acireductone dioxygenase 1 physically interacts with Arabidopsis thaliana G protein beta, and acireductone dioxygenase enzymatic activity is stimulated by Arabidopsis thaliana G protein beta in vitro. Overexpression of acireductone dioxygenase 1 suppresses the 2-day-old etiolated phenotype of agb1-2. Acireductone dioxygenase 1 and Arabidopsis thaliana G protein beta both control embryonic hypocotyl length by modulating cell division. They also may contribute to the production of ethylene, a product of the methionine salvage pathway. Arabidopsis thaliana G protein beta regulates acireductone dioxygenase 1 activity to control cell division, possible mechanism for Arabidopsis thaliana G protein beta activation of acireductone dioxygenase 1 activity, overview	-, 725438	
1.13.11.54	physiological function	the enzyme regulates the activity of matrix metalloproteinase I, which is involved in tumor metastasis, by binding the cytoplasmic transmembrane tail peptide of matrix metalloproteinase I	764179	
1.13.11.54	physiological function	transgenic rice plants overexpressing isoform ARD4 exhibit root growth characteristics including faster radical emergence, more rapid elongation of primary roots, early initiation of crown/lateral roots, and higher root biomass than the non-transgenic plants	765809