1.1.1.331	evolution	molecular phylogenetic analysis of specialized metabolic enzyme genes from lignan-producing plants, two common gene clusters include genes from various plants and plant lineage-specific gene clusters. The specialized metabolic enzyme genes from lignan-producing plants include enzymes involved in the early common lignan biosynthesis upstream of matairesinol such as PLR and SIRD, suggesting that they have occurred in their ancestral plants and conserved their biological functions	743611	
1.1.1.331	metabolism	the enzyme catalyzes a step in the podophyllotoxin biosynthesis pathway	763661	
1.1.1.331	metabolism	the enzyme is involved in the enzymatic cascade for (-)-podophyllotoxin biosynthesis	762561	
1.1.1.331	metabolism	the enzyme is involved in the lignan biosynthesis pathway, overview	743611	
1.1.1.331	metabolism	the enzyme is involved in the lignan biosynthetic pathways in Forsythia, overview	742033	
1.1.1.331	metabolism	the enzyme is part of the podophyllotoxin, PPT, biosynthetic pathway	-, 743278	
1.1.1.331	metabolism	the enzyme is part of the podophyllotoxin, PPT, biosynthetic pathway, overview. Podophyllotoxin is an important aryltetralin lignan, that possesses antitumor and antihyperlipidemic activities	743768	
1.1.1.331	additional information	the enzyme forms a homotetramer composed of an alpha/beta single domain structure with a dinucleotide-binding Rossmann fold for the binding of NAD+ and an active site with a highly conserved catalytic triad of amino acids, Ser153, Tyr167 and Lys171	743278	
1.1.1.331	physiological function	matairesinol biosynthesis is prominently enhanced and matairesinol is highly accumulated in callus	743611	
1.1.1.331	physiological function	the enzyme secoisolariciresinol dehydrogenase facilitates the dehydrogenation of secoisolariciresinol to form matairesinol, a mid-pathway intermediate product in podophyllotoxin, PPT, biosynthesis	-, 743278