1.1.1.267	evolution	Dioscorea zingiberensis DzDXR is highly homologous to other plant DXRs, especially to those in monocotyledons	762782	
1.1.1.267	evolution	phylogenetic analysis, rice DXR is encoded by the single copy gene OsDXR and phylogenetically categorized into plant DXR clade II, which includes the tree plants gingko, yew, and pine, and the Poaceae family plants sorghum (Sorghum bicolor), maize, foxtail millet, and barley (Hordeum vulgare). On the other hand, rice DXR is not categorized into clade I, which includes herbage plants	762871	
1.1.1.267	malfunction	DXR is essential for the survival of the pathogen, and its inhibition leads to the antimalarial action	763000	
1.1.1.267	malfunction	DXR is essential for the survival of the pathogen, and its inhibition leads to the antitubercular action	-, 763000	
1.1.1.267	malfunction	increased expression of SaDXR leads to increased contents of sandalwood sesquiterpenoids, such as alpha-santalol and beta-santalol, in the stems of young sandalwood trees	763120	
1.1.1.267	malfunction	overexpression of PtDXR in transgenic poplars improves tolerance to abiotic and biotic stresses. Increased transcript levels of PtDXR alter the response to Septotinia populiperda. The spread and extent of pathogens in the wild-type plants are faster and greater than in the transgenic lines, based on analysis of the length and width of the largest pathogenic region	763591	
1.1.1.267	malfunction	the overexpression of each OsDXS2 or OsDXR causes no positive effect on the accumulation of either carotenoids or chlorophylls in leaves and seeds, but overexpression of either OsDXS2 or OsDXR affects seed carotenoid metabolism, total carotenoid content is increased by 26% in the PGD1::OsDXS2 lines and decreased by 11% in the PGD1::OsDXR lines, overview. The endogenous expression of OsDXS1 and OsDXS2 increases up to 6.7fold and 4.0fold, respectively, following the overexpression of OsDXR, but the enhanced activity of OsDXS2 does not cause a significant increase in OsDXR expression, even though the expression of the OsPSY2 gene is significantly increased up to 5.7fold following the overexpression of OsDXS2	762871	
1.1.1.267	metabolism	1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is the first key enzyme in the MEP pathway for terpenoid biosynthesis	762667	
1.1.1.267	metabolism	1-deoxy-D-xylulose 5-phosphate-reductoisomerase (DXR,) is the key enzyme in the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. In contrast to the DzDXR transcription, diosgenin is present predominantly in tubers and in minute quantities in leaves. Because diosgenin is very likely formed mainly in the cytosol of mature leaf cells of Dioscorea zingiberensis and the plastidic IPP and DMAPP produced by the MEP pathway can be transported into the cytosol, the consistently high expression of DzDXR detected in mature leaf of Dioscorea zingiberensis implies that the MEP pathway might play a significant role in diosgenin biosynthesis	762782	
1.1.1.267	metabolism	1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) catalyzes the second step of the nonmevalonate (or MEP) pathway that functions in several organisms and plants for the synthesis of isoprenoids	-, 763000