6.1.1.22	malfunction	mutations of the mitochondrial asparaginyl-tRNA synthetase cause nonsyndromic deafness and leigh syndrome	
6.1.1.22	metabolism	asparaginyl-tRNA synthetase is a member of the class-II aminoacyl-tRNA synthetases, and is responsible for catalyzing the specific aminoacylation of tRNAAsn with asparagine	
6.1.1.22	physiological function	NARS is one of the important mediators of FGF2 induced survival signaling in osteoblasts through the activation of PI3K/Akt survival pathway	
6.1.1.22	physiological function	the enzyme is a highly expressed excretory-secretory molecule which activates interleukin 8 (IL-8) receptors via extracellular domains that are different from those used by IL-8	
6.1.1.22	physiological function	the enzyme induces endothelial cell proliferation, promotes chemotaxis and induces ring formation and tube formation by EA.hy926 cells. The enzyme induces vasodilation in chick embryo chorioallantoic membranes