5.1.3.8	evolution	AGE enzymes can be divided in 3 different groups,overview	-, 727105	
5.1.3.8	evolution	mammalian enzyme requires the presence of nucleotide activators and cofactors, while the bacterial enzyme are activated by nucleotide binding, but do not require them as cofactors	-, 747472	
5.1.3.8	metabolism	the biosynthesis of N-acetyl-D-mannosamine can be regulated in amammals in two different ways. In the liver, UDP-GlcNAc is epimerized to UDP-ManNAc by the bifunctional UDP-GlcNAc 2-epimerase, while in the kidney (mostly), GlcNAc is directly epimerized to ManNac by GlyNAc 2-epimerase	747472	
5.1.3.8	additional information	the majority of biocatalytic approaches for Neu5Ac synthesis involve an N-acylglucosamine 2-epimerase (AGE, EC 5.3.1.8) in combination with an N-acetylneuraminate lyase (NAL, EC 4.1.3.3)	749219	
5.1.3.8	additional information	three-dimensional structure modeling, overview	-, 727105	
5.1.3.8	physiological function	N-acyl-D-glucosamine 2-epimerase (AGE) is an important enzyme for the biocatalytic synthesis of N-acetylneuraminic acid (Neu5Ac)	749219