4.2.1.46	malfunction	inactivation of rmbB abolishes the production of doxorubicin while complementation of the same gene in an rmbB knockout mutant restores the doxorubicin production	
4.2.1.46	metabolism	the enzyme is involved in biosynthesis of dTDP-L-rhamnose, which is a sugar donor to the synthesis of the cell wall linker, D-N-acetylglucosamine-L-rhamnose	
4.2.1.46	metabolism	the enzyme is involved in the biosynthesis of the dTDP-3-amino-3,6-dideoxy-D-galactose and dTDP-3-amino-3,6-dideoxy-D-glucose	
4.2.1.46	metabolism	the enzyme is involved in the dTDP-rhamnose biosynthetic pathway	
4.2.1.46	physiological function	rmbB provides dTDP-4-dehydro-6-deoxy-D-glucose as a nucleotide sugar precursor for the biosynthesis of doxorubicin