4.1.3.16	malfunction	mutations are responsible for primary hyperoxaluria type III	
4.1.3.16	malfunction	enzyme deficiency leads to primary hyperoxaluria type 3	
4.1.3.16	malfunction	enzyme mutations ultimately lead to oxalate accumulation and stone formation in primary hyperoxaluria type 3	
4.1.3.16	malfunction	primary hyperoxaluria type 3 is due to mutations in the 4-hydroxy-2-oxoglutarate aldolase gene