3.5.1.13	evolution	PamH belongs to the amidase signature, AS, enzyme family. The Ser-Ser-Lys catalytic residues are highly conserved, indicating that there is an evolutionary relationship between the enzymes in the AS family	
3.5.1.13	evolution	the enzyme belongs to the amidase signature enzyme family	
3.5.1.13	evolution	the enzyme belongs to the nitrilase superfamily, subfamily in branch 13. The enzyme contains highly conserved E41-K107-C141 catalytic triad which is typical for nitrilase superfamily amidases	
3.5.1.13	additional information	the aryl acylamidase activity is associated with cobra venom acetylcholinesterase	
3.5.1.13	additional information	the enzyme maintains a core alpha/beta/alpha structure and the G-(GAV)-S-(GS)2-GX-(GSAE)-(GSAVYCT)-X-(LIVMT)-(GSA)-X6-(GSAT)-X-(GA)-X-(DE)-X-(GA)-X-S-(LIVM)-R-X-P-(GSACTL) sequence motif	
3.5.1.13	physiological function	aryl acylamidase activity of acetylcholinesterase is actively involved in the process of osteoblast differentiation and mineralization