3.4.24.85	malfunction	after heat treatment at 44°C, the enzyme knockout mutant cannot grow at all, whereas the wild type recovers from thermal damage quickly	754665	
3.4.24.85	malfunction	an enzyme knockout mutant is more sensitive to 120 mM ammonium chloride than the wild type	754667	
3.4.24.85	malfunction	enzyme gene ablation is compatible with parasite replication and stage conversion but results in reduced parasite development in late liver stages and in the asexual intra-erythrocytic cycle	755137	
3.4.24.85	metabolism	activation of the extracytoplasmic function sigma factor sigmaP by beta-lactams in Bacillus thuringiensis requires the site-2 protease RasP	-, 754811	
3.4.24.85	physiological function	cells defective in the site-2 protease gene have remarkably higher level of superoxide and elevated rates of cell death than wild-type CHO cells. Lack of the site-2 proease gene leads to cells more vulnerable to oxidative stress. Compared with wild-type CHO cells, mutant cells have higher nicotinamide adenine dinucleotide phosphate oxidase activity and lower paraoxonase-2 expression	735261	
3.4.24.85	physiological function	gene product is essential for growth. A partially segregated mutant displays defective acid acclimation to pH 6.5. Early acid acclimation to pH 6.5 in the wild-type strain includes upregulation of sigH, hik16 and hik35 and downregulation of pcrR and sigG, as well as downregulation of porins and upregulation of inorganic carbon and nitrogen transporters. The inability of the mutant strain to survive at pH 6.5 is related to defective photosynthesis and excess expression of NADH dehydrogenase, together with excessive upregulation of carbon transporter and repression of nitrogen transporter and metabolism genes. Slr0643 disruption and expression of the sigH operon are closely related	734641	
3.4.24.85	physiological function	HurP is essential for heme-dependent induction of bhuR and downstream genes	710497	
3.4.24.85	physiological function	knock-out of sll0528 gene increases Synechocystis sp. PCC 6803 sensitivity to salt, cold and hyperosmotic stress, as revealed by retarded growth, reduced pigments and disrupted photosystems	734002	
3.4.24.85	physiological function	loss-of-function mutant confers high sensitivity to abscisic acid during seed germination. Site-2 protease desensitizes abscisic acid signaling during seed germination through regulating the activation of the membrane-associated transcription factor bZIP17 and therefore controlling the expression level of genes encoding negative regulators of abscisic acid signaling	734789	
3.4.24.85	physiological function	RasP is involved in transmembrane stress signal transduction	720919	
3.4.24.85	physiological function	RseP introduces a cleavage into signal peptides after their signal peptidase-mediated liberation from preproteins. The enzyme is involved in degradation of remnant signal peptides left in the bacterial cytoplasmic membrane	720919	
3.4.24.85	physiological function	the enzyme is involved in activation of the crucial membrane-associated transcription factors deltaK during sporulation	710497	
3.4.24.85	physiological function	the enzyme is involved in the feedback regulation of sterol and fatty acid synthesis and uptake by controlling the activity of transcription factors, sterol regulatory element binding proteins. Through the S2P cascade, the cholesterol feedback pathway in humans is stringently regulated	710497	
3.4.24.85	physiological function	the enzyme is involved in the production of pheromone cAD1, cPD1, and cCF10, and inhibitor peptide iAD1 and iCF10.The enzyme processes the sex pheromone and inhibitor precursors as they pass through the cell membrane	710497	
3.4.24.85	physiological function	the enzyme is required for resistance to beta-lactams	-, 754811	
3.4.24.85	physiological function	the enzyme is the molecular target for baicalin in inducing endoplasmic reticulum stress-mediated hepatocellular carcinoma cell apoptosis	753581	
3.4.24.85	physiological function	the enzyme plays an important role in heat acclimation	754665	
3.4.24.85	physiological function	the enzyme plays an important role in the acclimation to ammonium stress in Synechocystis sp. PCC6803	754667