3.4.22.B27	malfunction	epidermal growth factor receptor degradation is slightly delayed in CAPN7-knockdown HeLa cells, the effect can be reversed by re-expression of wild-type enzyme CAPN7 but not a protease-inactive mutant	
3.4.22.B27	additional information	calpain-7 is a unique intracellular cysteine protease that has a tandem repeat of microtubule interacting and trafficking domains and lacks a penta-EF-hand domain. The catalytic residues are C290, H458 and N478	
3.4.22.B27	additional information	importance of not only the N-terminal microtubule-interacting and trafficking domains but also the C-terminal C2 domain-like domains for proteolytic activity of the enzyme	
3.4.22.B27	physiological function	the enzyme is involved in membrane trafficking. The proteolytic activity of CAPN7 is important for the acceleration of epidermal growth factor receptor degradation via the endosomal sorting pathway utilizing a part of the endosomal sorting complex required for transport, ESCRT, system