3.4.21.B26	evolution	the enzyme belongs to the Ca2+-dependent proprotein convertase family of enzymes	731899	
3.4.21.B26	evolution	the enzyme is a serine protease of the proprotein convertase family	732515	
3.4.21.B26	malfunction	complete knockout of PC5/6 is lethal between E4.5-7.5	718009	
3.4.21.B26	malfunction	enzyme-knockout endometrial epithelial cells show reduced capacity to attach to trophoblast spheroids and bind to fibronectin compared with control. Knockdown of the enzyme decreases cell surface presentation of functional integrins-alpha1, alpha2, alpha5, alphaV and alphaVbeta5	731899	
3.4.21.B26	malfunction	gene inactivation of PC5/6 leads to lethality at birth, the lack of PC5/6 in enterocytes results in a significantly higher tumor number in the duodenum, the absence of PC5/6 is also associated with a premature mortality of ApcMin/+ mice that harbor a heterozygote multiple intestinal neoplasia mutation in the adenomatous polyposis coli gene	709911	
3.4.21.B26	malfunction	PC5/6-knockout mouse embryos show developmental abnormalities, and reduced overall mineralization	753112	
3.4.21.B26	malfunction	PC6 knockdown reduces removal of alpha-dystroglycan N-terminus from endometrial epithelial cell surface and blastocyst adhesion	753529	
3.4.21.B26	malfunction	specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases BMP-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers	752449	
3.4.21.B26	malfunction	specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways	731111	
3.4.21.B26	metabolism	the enzyme in the human endometrium is tightly regulated during receptivity for embryo implantation	731899	
3.4.21.B26	metabolism	the enzyme is the proprotein convertase that is tightly regulated in the uterus during embryo implantation	731128	
3.4.21.B26	physiological function	full-length alpha-dystroglycan in the human endometrial epithelium is a barrier for embryo attachment and removal of the N-terminus by proprotein convertase 5/6 regulates receptivity. Removal of alpha-dystroglycan N-terminus is an important posttranslational control of endometrial receptivity and uterine fluid	753529	
3.4.21.B26	physiological function	involvement of PC5/6A in squamous differentiation of human nasal epithelial cells. Overexpression of PC5/6A and BMP-2 in the human nasal epithelial cell line RPMI-2650 demonstrates that PC5/6A can activate BMP-2	752449	
3.4.21.B26	physiological function	involvement of the enzyme in squamous differentiation of human nasal epithelial cells possibly through up-regulation of the BMP-2/pSmad1/5/8/p38 signaling pathway	731111	
3.4.21.B26	physiological function	Pcsk5/PCSK5 is temporally and spatially expressed with Opn/OPN (Spp1/SPP1) in osteoblasts and osteocytes, indicating that osteopontin could be a physiologically relevant substrate for PC5/6 or PC5/6-activated proteases in bone. Cleavage of osteopontin may modify the function of osteopontin in bone and/or modulate other enzymatic cleavages of osteopontin, leading to alterations in the bone phenotype	753112	
3.4.21.B26	physiological function	pro-integrins-alpha in the endometrial epithelium are post-translationally cleaved by the enzyme into functional subunits for the binding of blastocyst and adhesion of extracellular matrix proteins, the enzyme is responsible for the post-translational cleavage of pro-integrin-alpha5 and integrin-alphaV into their heavy and light chains in HEC-1-A cells. The integrins are transmembrane glycoproteins, some of which play an important role in the adhesive interactions between the trophoblast (blastocyst) and uterine epithelium at implantation	731899	
3.4.21.B26	physiological function	proprotein convertase 5/6 cleaves and activates platelet-derived growth factor A in the human endometrium in preparation for embryo implantation, overview. The enzyme plays an important role in converting precursor proteins into their active forms through specific proteolysis	732515	
3.4.21.B26	physiological function	the enzyme is critical for receptivity establishment in women, endometrial enzyme is secreted into the uterine fluid, and levels correlate with receptivity status	731128	
3.4.21.B26	physiological function	the proprotein convertase PC5/6 is protective against intestinal tumorigenesis	709911