3.1.1.118	malfunction	deleterious mutations in the enzyme cause the SPG28 subtype of the neurological disease Hereditary Spastic Paraplegia which is characterized by axonal neuropathy and gait impairments. Enzyme inactivation causes a substantial decrease in polyunsaturated lysophosphatidylinositol lipids and an corresponding increase in phosphatidylinositol lipids	760595	
3.1.1.118	malfunction	enzyme depletion causes enlargement of early endosomes and stimulated tabulation of recycling endosomes positive for phosphatidic acid-binding proteins syndapin2 and MICAL-L1. Enzyme knockout enhances transferrin recycling from recycling endosomes to the cell surface	761130	
3.1.1.118	malfunction	enzyme downregulation reduces in vitro colon cancer cell viability and increases apoptosis rate, without affecting normal cells	761626	
3.1.1.118	malfunction	enzyme gene disruption in mice causes sperm malformation due to mitochondrial organization defects	761448	
3.1.1.118	malfunction	enzyme mutations are responsible for hereditary spastic paraplegia	762106	
3.1.1.118	malfunction	enzyme mutations can lead to hereditary spastic paraplegia associated with retinal dystrophy and a pattern of neurodegeneration with brain iron accumulation	750476	
3.1.1.118	malfunction	the misregulation of the enzyme gene by Aft1/2 transcription factors alters cardiolipin metabolism and causes mitochondrial dysfunction in the cells	761452	
3.1.1.118	metabolism	overexpression of KIAA0725p causes dispersion of the endoplasmic reticulum-Golgi intermediate compartment and Golgi apparatus	761430	
3.1.1.118	metabolism	the enzyme regulates brain lysophospholipid and phosphatidylinositol content in vivo	760595	
3.1.1.118	metabolism	the phospholipase activity of the enzyme is required to allow access of the lipase to triglyceride molecules contained in the core of the lipid droplets	761660	
3.1.1.118	physiological function	the activity of the enzyme is necessary for the prevention of neurite elongation. The enzyme negatively controls the formation of a local phosphatidic acid-rich domain in recycling endosomes that serves as a membrane source for neurite outgrowth	761130	
3.1.1.118	physiological function	the enzyme plays a regulatory role in spermatogenesis or sperm function	762298	
3.1.1.118	physiological function	the enzyme regulates mitochondrial dynamics and is involved in the organization of mitochondria during spermiogenesis	761448	
3.1.1.118	physiological function	the enzyme supports colon cancer cell proliferation and survival	761626