2.6.1.19	evolution	EctB-type proteins are highly conserved	-, 759234	
2.6.1.19	evolution	enzyme Atu3300 is predicted by Pfam to include an Aminotrans_3 (aminotransferase class-III) domain, which is characteristic of aminotransferases	-, 760153	
2.6.1.19	evolution	transaminases structure comparisons, overview	-, 758736	
2.6.1.19	malfunction	constitutive overexpression lines of GABA-T are generated in Arabidopsis. Brief cold treatments increases leaf GABA concentrations in both the WT and transgenic line OX1, but the concentrations in OX1 is consistently lower. These findings confirm that GABA-T limits the catabolism of GABA when its production is stimulated by stress, and suggest a bioengineering strategy for improving the availability of succinate semialdehyde for the Krebs cycle or GLYR1, a potential redox-modulating reaction during stress	721953	
2.6.1.19	malfunction	deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT NCgl2515-deleted GAD strain remains unaltered when pH is maintained at pH 7.5-7.8, demonstrating that GABA decomposition is reduced	-, 760076	
2.6.1.19	malfunction	deletion of the gabT gene encoding GABA-T cannot prevent GABA from decomposing at neutral pH. An additional transaminase gene, NCgl2515, is deleted in a gabT-deleted GAD strain, but the GABA concentration in this gabT-deleted GAD strain NCgl2515 remains unaltered when pH is maintained at pH 7.5-8.0, demonstrating that GABA decomposition is reduced	-, 760076	
2.6.1.19	malfunction	IncRNAs play an important role in the regulation of gene expression. Differential expression of lncRNAs (DELs) and mRNAs (DEMs) in myelodysplastic syndrome (MDS), profiling to construct a 4-aminobutyrate aminotransferase (ABAT)-DEL-DEM coexpression network in MDS development using the GO and KEGG pathway and network analyses. Compared with controls, there are 543 DELs and 2705 DEMs in MDS patients, among which 285 (52.5%) DELs are downregulated and 258 (47.5%) DELs are upregulated, whereas 1521 (56.2%) DEMs are downregulated and 1184 (43.70%) DEMs are upregulated in MDS patients. The ABAT-DEL-DEM coexpression network contains six DELs that are coexpressed with ABAT in MDS	759881	
2.6.1.19	malfunction	inhibition of GABA aminotransferase (GABA-AT), the enzyme that degrades GABA, is a possible strategy for the treatment of substance abuse. The raised GABA levels that occur as a consequence of the inhibition antagonize the rapid release of dopamine in the ventral striatum (nucleus accumbens) that follows an acute challenge by an addictive substance. In addition, increased GABA levels are also known to elicit an anticonvulsant effect in patients with epilepsy	759407	
2.6.1.19	malfunction	inhibition of GABAT is known to boost GABA concentration in the brain and thereby alleviates spasticity. Therefore, attenuating GABAT activity and enhancing GABA expression are a promising way to relieve spasticity following stroke. Waggle needling attenuates gamma-aminobutyric acid transaminase expression in the injured brain of rats with post-stroke spasticity comparable to the effect of baclofen	-, 759852	
2.6.1.19	malfunction	patients with GABA-T deficiency show severe, nonspecific neurological manifestations, including psychomotor retardation, epilepsy, hypotonia, and hyperreflexia	704969	
2.6.1.19	metabolism	GABA metabolism	698627	
2.6.1.19	metabolism	GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism	-, 759852	
2.6.1.19	metabolism	in cyanobacteria 2-oxoglutarate dehydrogenase (2-OGDH) is missing. A bypass route via succinic semialdehyde (SSA), which utilizes 2-oxoglutarate decarboxylase (OgdA) and succinic semialdehyde dehydrogenase (SsaD) to convert 2-oxoglutarate (2-OG) into succinate, is identified, thus completing the TCA cycle in most cyanobacteria. In addition to the glyoxylate shunt that occurs in a few of cyanobacteria, the existence of a third variant of the TCA cycle connects these metabolites. The gamma-aminobutyric acid (GABA) shunt, is considered to be ambiguous because the GABA aminotransferase is missing in many cyanobacteria. N-acetylornithine aminotransferase (ArgD) can function as a GABA aminotransferase and, together with glutamate decarboxylase (GadA), it can complete a functional GABA shunt. Metabolite profiling of seven Synechococcus sp. PCC 7002 mutant strains related to these two routes to succinate proves the functional connectivity	759240	
2.6.1.19	metabolism	the enzyme takes part in the GABA shunt pathway and GABA uptake/assimilation pathway in Corynebacterium glutamicum	-, 758736	
2.6.1.19	metabolism	unlike GabT, which exhibits high GABA-T activity and utilizes only 2-oxoglutarate as amino acceptor, the purified NCgl2515 protein exhibits very low GABA-T activity only when coupled with succinate-semialdehyde dehydrogenase (SSADH) GabD, but can utilize both 2-oxoglutarate and pyruvate as amino acceptor	-, 760076	
2.6.1.19	metabolism	unlike GabT, which exhibits high GABA-T activity and utilizes only 2-oxoglutarate as amino acceptor, the purified NCgl2515 protein exhibits very low GABA-T activity only when coupled with succinate-semialdehyde dehydrogenase (SSADH), GabD, but can utilize both 2-oxoglutarate and pyruvate as amino acceptor	-, 760076	
2.6.1.19	additional information	active site structure analysis, the epsilon-amino group of Lys288, the catalytic residue of CgGABA-AT, may form an internal aldimine with the aldehydic carbon of PLP, which is required for catalysis	-, 758736	
2.6.1.19	additional information	bioinformatic analysis of lncRNAs correlated to enzyme ABAT	759881	
2.6.1.19	additional information	homology structure modeling using pig ABAT as template (PDB ID 6B6G)	758692	
2.6.1.19	additional information	structural homology modeling of (Pl)EctB usimg the crystal structure of the GABA transaminase from Arthrobacter aurescens (PDB ID 4ATP, EC 2.6.1.19) as template	-, 759234	
2.6.1.19	physiological function	Arabidopsis thaliana GABA-T functionally complements a Saccharomyces cerevisiae Uga1 mutant lacking GABA transaminase activity, despite mitochondrial localization of the Arabidopsis thaliana enzyme and cytosolic localization of the yeast enzyme. Recombinant GABA-T rescues mutant yeast's GABA growth defect, thermosensitivity and limiting production of reactive oxygen species, but GABA-T is about half as efficient in doing so Saccharomyces cerevisiae Uga1 gene product	739761	
2.6.1.19	physiological function	GABA-T acts in salt responses in linking N and C metabolisms in roots, GABA-T is the most responsive step of GABA metabolism upon NaCl stress	702914	
2.6.1.19	physiological function	GabT activity of the recombinant Escherichia coli enzyme expressed in Agrobacterium tumefaciens enhances the T-DNA transfer ability of Agrobacterium tumefaciens	760153	
2.6.1.19	physiological function	gamma-aminobutyric acid (GABA) is one of the chief inhibitory neurotransmitters in the central nerve system (CNS), plays pre- or postsynaptic inhibitory effects. GABA transaminase (GABAT) is the key catabolic enzyme of GABA metabolism. The modulation of GABA and its metabolism by acupuncture, particularly waggle needling, might attenuate GABAT and enhance GABA, alleviating post-stroke spasticity	-, 759852	
2.6.1.19	physiological function	gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the central nervous system. The enzyme GABA aminotransferase (GABA-AT) degrades GABA	759407	
2.6.1.19	physiological function	isoform GABA-T1 plays the predominant role in GABA metabolism in vegetative tissue	704882	
2.6.1.19	physiological function	loss of GABA transaminase increases sleep, and affects metabolism such that flies lacking GABA transaminase fail to survive on carbohydrate media. GABA degradation product glutamate, rather than succinic semialdehyde, accounts for the metabolic phenotype of the mutants. Inhibition of GABA transaminase affects energetic pathways. Mutants display a general disruption in bioenergetics. The effects of GABA transaminase on sleep do not depend upon glutamate, indicating that GABAT regulates metabolic and sleep homeostasis through independent mechanisms	738656	
2.6.1.19	physiological function	mutations in the enzyme cause an autosomal recessive neurometabolic disorder and mitochondrial DNA depletion syndrome (MDS). ABAT functions in the mitochondrial nucleoside salvage pathway to facilitate conversion of dNDPs to dNTPs. Inhibition of ABAT by Vigabatrin causes depletion of mtDNA in photoreceptor cells that is prevented through addition of dNTPs in cell culture media	738002	
2.6.1.19	physiological function	N-acetylornithine aminotransferase is a bifunctional enzyme that has both N-acetylornithine aminotransferase (EC 2.6.1.11) and GABA aminotransferase activities. N-acetylornithine aminotransferase (ArgD) can function as a GABA aminotransferase and, together with glutamate decarboxylase (GadA), it can complete a functional GABA shunt, metabolic profiling of glutamate decarboxylase expression strains	759240	
2.6.1.19	physiological function	N-acetylornithine aminotransferase is a bifunctional enzyme that has both N-acetylornithine aminotransferase (EC 2.6.1.11) and GABA aminotransferase activities. N-acetylornithine aminotransferase (ArgD) can function as a GABA aminotransferase and, together with glutamate decarboxylase (GadA, from Synechococcus sp. strain 6803) which is recombinantly expressed in strain Synechococcus sp. 7002, it can complete a functional GABA shunt, metabolic profiling of glutamate decarboxylase expression strains	759240	
2.6.1.19	physiological function	production of glutaric acid depends on the expression of native gabT (EC 2.6.1.48) and gabD of Corynebacterium glutamicum, or on heterologous expression of davT (EC 2.6.1.48) and davD (EC 1.2.1.20) from Pseudomonas putida encoding 5-aminovalerate aminotransferase, and glutarate semialdehyde, respectively	754623	
2.6.1.19	physiological function	the Agrobacterium tumefaciens ability to mediate inter-kingdom DNA transfer in plant genetic engineering is inhibited by gamm-aminobutyric acid (GABA)	760153