2.5.1.141	malfunction	deletion of the enzyme gene attenuates growth and virulence in mice but enhances pigment production and formation of quinolone tolerant persister cells in stationary phase	-, 759239	
2.5.1.141	malfunction	without this enzyme, Staphylococcus aureus is repressed in its ability to secrete cytolytic toxins	-, 743825	
2.5.1.141	metabolism	the enzyme is essential for processing heme into the electron transport chain for use as an electron acceptor	-, 743825	
2.5.1.141	metabolism	the enzyme plays a role in heme A and heme O synthesis and seems to be required for both cytochrome a and cytochrome o synthesis	743298	
2.5.1.141	metabolism	the synthesis of the heme a cofactor used in cytochrome c oxidase is dependent on the sequential action of heme o synthase and heme a synthase	-, 727913	
2.5.1.141	physiological function	the assembly and activity of cytochrome c oxidase is dependent on the availability of heme A, one of its essential cofactors. In eukaryotes, two inner mitochondrial membrane proteins, heme O synthase (Cox10) and heme A synthase (Cox15), are required for heme A biosynthesis. The two physiological partners do not share the same regulatory mechanism. The stoichiometry between Cox15 and Cox10 is 8:1, not 1:1 as it has generally been assumed	-, 727866	
2.5.1.141	physiological function	the enzyme catalyzes the first step in the conversion of protoheme to the heme A prosthetic groups of the cytochrome c oxidase	727609	
2.5.1.141	physiological function	the enzyme is involved in persister cell formation under stress and antibiotic treatment	-, 759239