2.4.1.65 malfunction mice lacking both isoforms FUT4 and FUT7 have a shorter time to occlusive thrombus formation in the injured carotid artery and a higher mortality due to collagen/epinephrine-induced pulmonary thromboemboli. FUT4-, but not FUT7, -deficient mice have increased pulmonary thromboembolism-induced mortality and decreased thromboemboli dissolution in vivo 735422 2.4.1.65 malfunction sperm isoform FUT5 pretreatment or blocking suppresses the protective effect of OE-E6/E7 membrane proteins on sperm motility 736817 2.4.1.65 metabolism isoform Fut3 expression drives sialyl Lewis A synthesis in V6 variant of CD44-expressing cells 736582 2.4.1.65 metabolism isoforms FUT4 and FUT7 are required for the synthesis of functional selectin-type leukocyte adhesion molecule ligands 735422 2.4.1.65 physiological function alpha(1,3) fucosyltransferases IV and VII are essential for the initial recruitment of basophils in chronic allergic inflammation 736601 2.4.1.65 physiological function alpha-1,3 fucosyltransferases can enhance metastatic efficiency of prostate cancer by triggering an endothelial selectin-dependent trafficking mechanism. Upregulated FT3, FT6, or FT7 expression induces robust prostate cancer PC-3 cell adhesion to bone marrow endothelium and to inflamed postcapillary venules in an endothelial selectin-dependent manner. FT3, FT6, and FT7 induce sialyl Lewis X expression on metastatic prostate cancer PC-3 cells. Elevated FT7 expression promotes PC-3 cell trafficking to and retention in bone marrow through an endothelial selectin dependent event 706522 2.4.1.65 physiological function final glycosylation step in sialyl Lewis x and sialyl Lewis a biosynthesis in MKN45 cell line is associated to FUT5, which efficiently fucosylates sialyl Lewis precursors on glycoproteins 704049 2.4.1.65 physiological function fucosyltransferases are responsible for the synthesis of sialyl Lewis a and sialyl Lewis x in gastrointestinal cell lines 704049 2.4.1.65 physiological function Helicobacter pylori-binding glycosphingolipid isolated from stomach of transgenic alpha-1,3/4-fucosyltransferase-expressing mice as a Fucalpha2Galbeta3 (Fucalpha4)GalNAcbeta4Galbeta4Glcbeta1Cer, i.e. a Leb-like glycosphingolipid on a ganglio core structure. Two other glycosphingolipids are isolated from the mouse stomach epithelium that are found to be nonbinding with regard to Helicobacter pylori, which is a pentaglycosylceramide, GalNAcbeta3Galalpha3(Fucalpha2)Galbeta4Glcbeta1Cer, in which the isoglobo tetrasaccharide is combined with Fucalpha2 to yield an isoglobotetraosylceramide with an internal blood group B determinant. The second one is an elongated fucosyl-gangliotetraosylceramide, GalNAcbeta3(Fucalpha2)Galbeta3GalNAcbeta4Galbeta4Glcbeta1Cer 703893 2.4.1.65 physiological function isoform FUT4 and FUT7 activity regulates thrombosis in a P-selectine and P-selectin glycoprotein ligand-1-independent manner. Isoform FUT4 activity is important for thrombolysis 735422 2.4.1.65 physiological function role in synthesis of parasitic GalNAc beta1-4(Fuc alpha1-3)GlcNAc beta-R antigen 703056 2.4.1.65 physiological function sperm isoform FUT5 binds to human oviductal epithelial cells 736817 2.4.1.65 physiological function the enzyme improves the function of selectin ligands on cord blood hematopoietic stem cells 736194 2.4.1.65 physiological function the enzyme plays an important role in hepatocellular carcinoma growth by regulating the PI3K/Akt signaling pathway. Elevating enzyme expression markedly induces intracellular Akt phosphorylation, and suppresses the expression of the cyclin-dependent kinases inhibitor p21. Enzyme overexpression of enhances S-phase cell population, promotes cell growth and colony formation ability 721501