2.1.1.68	evolution	transcriptome and metabolome analyses of Rauwolfia serpentina roots allow the identification of 7 candidate O-methytransferase (OMT) genes that might be associated with the formation of 3,4,5-trimethoxybenzoate and 3,4,5-trimethoxycinnamate. RsOMT1 is a member of the caffeoyl CoA-OMT-like family of genes	757937	
2.1.1.68	evolution	transcriptome and metabolome analyses of Rauwolfia serpentina roots allow the identification of 7 candidate O-methytransferase (OMT) genes that might be associated with the formation of 3,4,5-trimethoxybenzoate and 3,4,5-trimethoxycinnamate. RsOMT3 is a member of the caffeic acid-OMT-like family of genes	757937	
2.1.1.68	malfunction	Arabidopsis COMT1 knockout mutant line Atomt1 lignin differs from native lignin in wild type plants, in terms of sinapyl (S) alcohol-derived substructures in fiber cell walls being substituted by 5-hydroxyconiferyl alcohol (5OHG)-derived moieties	720616	
2.1.1.68	malfunction	downregulation of CCR1 and caffeic acid O-methyltransferase 1 (OMT1) using an RNA interference-mediated silencing strategy causes dramatic changes in lignin level and composition in transgenic perennial ryegrass plants grown under both glasshouse and field conditions. Both field-grown OMT1-deficient and CCR1-deficient perennial ryegrass plants show enhanced digestibility without obvious detrimental effects on either plant fitness or biomass production	720676	
2.1.1.68	malfunction	enzyme knockdown suppresses host resistance to sharp eyespot	758439	
2.1.1.68	malfunction	transformation of Arabidopsis loss-of-function Atomt1 mutant with a FGCOMT1 cDNA partially complements accumulation of sinapoyl derivatives but does not function to produce the major methylated flavonol isorhamnetin in seeds	720423	
2.1.1.68	metabolism	3,4-dihydroxybenzaldehyde is not the preferred substrate. The higher catalytic efficiency of the purified recombinant enzyme with the substrates caffeoyl aldehyde and 5-hydroxyconiferaldehyde, and its tissue distribution, suggest this methyltransferase may primarily unction in lignin biosynthesis	718207	
2.1.1.68	metabolism	enzyme overexpression increases melatonin levels in tomato plants	757491	
2.1.1.68	metabolism	involvement of RsOMT1 and RsOMT3 in the assembly of trimethoxybenzoic and trimethoxycinnamic acids	757937	
2.1.1.68	metabolism	transgenic rice plants overexpressing the enzyme show an increase in melatonin levels	757324	
2.1.1.68	physiological function	an Arabidopsis thaliana knockout mutant exhibits less production of melatonin than the wild type when leaves are infiltrated with 1 mM N-acetylserotonin	734548	
2.1.1.68	physiological function	O-methyltransferase COMT6-deficient mutant Bd5139 displays a moderately altered lignification in mature stems. The COMT6 gene is also expressed in grains, and the alterations of Bd5139 grain lignins mirror nicely those evidenced in stem lignins. The Bd5139 grains display similar size and composition to the control. Introducing the mutated gene into the COMT1-deficient Arabidopsis thaliana mutant demonstrates that the mutated COMT6 protein is still functional. The moderate down-regulation of lignin-related COMT enzyme reduces the straw recalcitrance to saccharification, without compromising the vegetative or reproductive development of the plant	734390	
2.1.1.68	physiological function	OMT1 plays a key role in biosynthesis of both syringyl- and guaiacyl-lignin subunits in perennial ryegrass	720676	
2.1.1.68	physiological function	the enzyme positively contributes to both wheat resistance against sharp eyespot and stem mechanical strength possibly through promoting lignin (especially syringyl monolignol) accumulation	758439	
2.1.1.68	physiological function	the monoterpenoid indole alkaloids, reserpine and rescinnamine contain 3,4,5-trimethoxybenzoate or 3,4,5-trimethoxycinnamate, respectively, within their structures and they accumulate in different plant organs and particularly within roots of Rauwolfia serpentina. This plant also accumulates acylated sugars substituted with 3,4,5-trimethoxybenzoate and 3,4,5-trimethoxycinnamate	757937	
2.1.1.68	physiological function	transgenic plants exhibit higher salt stress tolerance. Enzyme overexpression significantly enhances the antioxidant capability, with higher antioxidant enzyme activity observed, including superoxide dismutase, peroxide and catalase activity, and higher ascorbic acid and glutamate accumulation levels. Enzyme overexpression also maintains good nutrient homeostasis in the tomato plants. Enzyme overexpression increases the SOS pathway genes and stress-related genes under salt stress	757491	
2.1.1.68	physiological function	transgenic plants overexpressing artificial microRNA to silence BdCOMT4 show altered flowering time and increased stem count and weight. Downregulated plants exhibit a reduction in total lignin content and decreased Maule staining of syringyl units in stem	733569