2.1.1.179	evolution	FmrO shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	evolution	RmtA shows aquired N7-G1405 16S-RMTase activity	719353	
2.1.1.179	evolution	RmtB shows aquired N7-G1405 16S-RMTase activity	719353	
2.1.1.179	evolution	RmtC shows aquired N7-G1405 16S-RMTase activity	-, 719353	
2.1.1.179	evolution	RmtD shows aquired N7-G1405 16S-RMTase activity	719353	
2.1.1.179	evolution	RmtD2 shows aquired N7-G1405 16S-RMTase activity	719353	
2.1.1.179	evolution	RmtF is a member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family	-, 718603	
2.1.1.179	additional information	acquisition of rmtC does not entail a fitness cost for the bacterium	-, 718596	
2.1.1.179	additional information	GrmA shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	additional information	GrmB shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	additional information	Kmr shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	additional information	NbrB shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	additional information	Sgm shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	additional information	Smr1 shows intrinsic N7-G1405 16S-RMTase activity	719353	
2.1.1.179	physiological function	encodes an enzyme that modifies 16S rRNA and thereby confers resistance to 4,6-disubstituted deoxystreptamine aminoglycosides. The expression of the sgm gene is regulated by the translational autorepression	704254	
2.1.1.179	physiological function	G1405 methylation produces aminoglycoside resistance by diminishing the affinity of the ribosome for gentamicin	712738	
2.1.1.179	physiological function	methylation of C1405, involved in the binding of aminoglycosides to 16S rRNA, can lead to loss of affinity and to resistance of the host. Resistance conferred by RmtF cannot be transferred to Escherichia coli via transfer of plasmid pIP849	-, 718603	
2.1.1.179	physiological function	most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis, These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview	719353	
2.1.1.179	physiological function	most aminoglycosides bind to the decoding aminoacyl-tRNA recognition site (A-site) of the 16S rRNA that composes bacterial 30S ribosome, and subsequently interfere with bacterial growth through blocking of protein synthesis. These aminoglycoside-producing actinomycetes are inherently resistant to aminoglycosides, because they harbor intrinsic 16S rRNA methyltransferase genes, that can confer aminoglycoside resistance to bacteria by modifying specific nucleotide residues in the aminoglycoside binding site of 16S rRNA. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview	719353	
2.1.1.179	physiological function	rmtC is responsible for resistance of strain ARS68 and its transformant to various aminoglycoside antibiotics	-, 710880	
2.1.1.179	physiological function	the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview	-, 719353	
2.1.1.179	physiological function	the enzyme adds the methyl group of S-adenosyl-L-methionine to the specific nucleotides at the A-site of 16S rRNA, which interferes with aminoglycoside binding to the target. Pseudomonas aeruginosa clinical isolates show high-level resistance to clinically useful aminoglycosides through the production of acquired 16S-RMTase. Aminoglycoside resistance profile provided by N7-G1405 16S-RMTases, overview	719353	
2.1.1.179	physiological function	the enzyme confers high-level resistance to 4,6-disubstituted aminoglycosides through methylation of the G1405 residue in the 16S rRNA. RmtC impedes methylation by the housekeeping methyltransferase RsmF, EC 2.1.1.178, at position C1407	-, 718596	
2.1.1.179	physiological function	the enzyme confers high-level resistance to aminoglycosides	-, 735238	
2.1.1.179	physiological function	the enzyme gives resistance to kanamycin plus gentamicin by converting guanine1405 to 7-methylguanine	705105	
2.1.1.179	physiological function	the enzyme produced by the antibiotic-producing bacterium Micromonospora zionensis methylates guanine1405 in 16S rRNA to 7-methylguanine, thereby rendering the ribosome resistant to 4,6-disubstituted deoxystreptamine aminoglycosides, which include gentamicins and kanamycins	705972