1.8.2.3 metabolism one of the central enzymes of the respiratory chain in sulfur-oxidizing bacteria 1.8.2.3 metabolism without sulfide:quinone oxidoreductase (SQR) Cupriavidus necator H16 uses flavocytochrome c sulfide dehydrogenase (FCSD) to oxidize self-produced sulfide and FCSD couples with persulfide dioxygenase (PDO) to oxidize sulfide to sulfite and thiosulfate, via a pathway similar to the SQR-PDO pathway 1.8.2.3 physiological function flavocytochrome c sulfide dehydrogenase enhances thiosulfate oxidation by the sulfur-oxidizing (Sox) system but couples with the Sox system for sulfide oxidation to sulfate in the absence of sulfide:quinone oxidoreductase 1.8.2.3 physiological function the enzyme plays a detoxification role in Cupriavidus necator H16. With the fccA and fccB genes encoding flavocytochrome c sulfide dehydrogenases Cupriavidus necator H16 oxidizes self-produced H2S