1.1.1.267	metabolism	1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is a rate-limiting enzyme that transforms 1-deoxy-D-xylulose 5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) and controls flux through the MEP pathway. Relationship between SaDXR and the biosynthesis of chlorophylls, carotenoids, and sandalwood-specific sesquiterpenoids, overview	763120	
1.1.1.267	metabolism	1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR), an important enzyme in the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway in plant plastids, provides the basic five-carbon units for isoprenoid biosynthesis. Roles of the MEP pathway in regulating growth, development, and artemisinin biosynthesis of Artemisia annua	763576	
1.1.1.267	metabolism	1-deoxy-D-xylulose-5-phosphate synthase (DXS) and 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) are key enzymes in terpenoid biosynthesis. The first two rate-limiting enzymes in the plastid-located 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway are 1-deoxy-D-xylulose-5-phosphate synthase (DXS) and 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). The first major step involves DXS-dependent catalysis of pyruvate and D-glyceraldehyde-3-phosphate to form 1-deoxy-D-xylulose-5-phosphate (DXP). The second step is catalyzed by DXR and generates MEP, followed by several enzymatic reactions to produce precursors of IPP and DMAPP. DXS catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate (DXP) from pyruvate and D-glyceraldehyde-3-phosphate. DXR catalyzes the formation of 2-C-methyl-D-erythritol 4-phosphate (MEP) from DXP	763591	
1.1.1.267	metabolism	1-deoxy-D-xylulose-5-phosphate, DXP, reductoisomerase catalyzes the first committed step in the 2-C-methyl-D-erythritol 4-phosphate pathway involving a skeletal rearrangement of DXP via a retroaldol/aldol process followed by reduction by NADPH to yield 2-C-methyl-D-erythritol 4-phosphate	724374	
1.1.1.267	metabolism	induction of DXR expression causes increased thymol and carvacrol production	748373	
1.1.1.267	metabolism	organ-specific differential roles of rice Deoxyxylulose 5-phosphate synthase (DXS) and deoxyxylulose 5-phosphate reductoisomerase (DXR), the first two enzymes of the methylerythritol 4-phosphate (MEP) pathway, in carotenoid metabolism in Oryza sativa leaves and seeds. DXS and DXR are the enzymes that catalyze the first two enzyme steps of the MEP pathway to supply the isoprene building-blocks of carotenoids. Enzyme OsDXS2 functions as a rate-limiting enzyme supplying IPP/DMAPPs to seed carotenoid metabolism, but OsDXR does not in either leaves or seeds. Carotenoid and MEP pathway regulation, overview	762871	
1.1.1.267	metabolism	rate-limiting enzyme in the 2-methyl-D-erythritol-4-phosphate (MEP) terpenoid biosynthetic pathway catalyzing the second step	763482	
1.1.1.267	metabolism	the 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR) is the rate-limiting enzyme in the methylerythritol 4-phosphate pathway (MEP) via conversion of 1-deoxy-D-xylulose-5-phosphate (DXP) into MEP	762525	
1.1.1.267	metabolism	the 1-deoxy-D-xylulose-5-phosphate reductoisomerase is the second enzyme in the nonmevalonate isoprene biosynthesis pathway, catalyzing the reductive isomerization of 1-deoxy-D-xylulose-5-phosphate to 2-methyl-D-erythritol-4-phosphate for making isopentenyl diphosphate and dimethylallyl diphosphate	723812	
1.1.1.267	metabolism	the enzyme catalyzes the first comitted step in the methyl erythritol phosphate (MEP) pathway	-, 760333