3.4.22.57	down	c-Rel is a negative regulator of caspase-4, e.g. in EBV lymphoblastoid cells	718292	
3.4.22.57	down	the dominant negative form of IkappaBalpha suppresses the expression of caspase-4	732677	
3.4.22.57	additional information	c-Rel as well as other endoplasmic reticulum stress genes directly modulate expression of caspase-4	718292	
3.4.22.57	up	apoptosis-independent cell death is accompanied by increased expression of the inflammatory marker, caspase-4. Caspase-4 is upregulated in Pt1 cells and induced by interferons	718292	
3.4.22.57	up	caspase-4 protein expression is strongly induced in the lesional stratum corneum of patients suffering from psoriasis, a common chronic inflammatory disease	717945	
3.4.22.57	up	enhancement of nuclear factor-kappaB activity by p65 (RelA) overexpression increases the expression of caspase-4 at both mRNA and protein levels	732677	
3.4.22.57	up	mRNA expression of the pro-form of caspase-4 is up-regulated 2fold after poly-I:C stimulation	732238	
3.4.22.57	up	tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation	718027