3.4.22.40	down	interferon-gamma significantly reduces the expression of bleomycin hydrolase. The enzyme activity and expression are markedly decreased in atopic dermatitis lesional and non-lesional skin (to 27.1 and 8.8%, respectively)	717865	
3.4.22.40	additional information	interleukin-4 does not show any direct effect on bleomycin hydrolase expression	717865	
3.4.22.40	up	bleomycin hydrolase expression is up-regulated via IRF-1/2, MZF-1 and Sp-1. mRNA is up-regulated in keratinocytes when cultured at high calcium concentration (6.8fold)	717865