3.1.6.12	down	exposure to 5alpha-dihydrotestosterone increases ARSB and DKK3 promoter methylation, resulting in decreased expression	752087	
3.1.6.12	additional information	differences in distribution, intensity, and pattern of ARSB staining among normal colon, adenomas, and adenocarcinomas is shown. Distinctive, intense luminal membrane staining is present in the normal epithelial cells but reduced in the malignancies and less in the grade 3 than in the grade 1 adenocarcinomas. In the normal cores, a distinctive pattern of intense cytoplasmic positivity at the luminal surface is followed by reduced staining deeper in the crypts	715789