2.4.1.224	down	EXT1 is significantly decreased in MCF7 cells compared with the non-tumorigenic MCF10A cells, while no significant difference is observed between the two triple-negative cell lines, MDA-MB-231 and HCC38, and the ER- and PR-positive MCF10A cells	758941	
2.4.1.224	down	the expression of EXT2 is reduced in all cancer cell lines	758941	
2.4.1.224	down	the overall transcriptional activity of the main heparan sulfate biosynthesis-involved genes (EXT1, EXT2, NDST1,NDST2, GLCE, HS2ST1, HS3ST1, HS3ST2, HS6ST1, HS6ST2, SULF1, SULF2, HPSE) is decreased by 1.5-2fold in Grade II-III glioma (p < 0.01) and by 3-fold in Grade IV glioma (glioblastoma multiforme, GBM) (p < 0.05), as compared with the para-tumourous tissue	759360