3.5.3.18	additional information	DDAH isoforms are expressed in a dynamic,overlapping pattern during embryonic development	712183	
3.5.3.18	up	alpha-lipoic acid increases the gene expression and activity of DDAH, and signal transducer and activator of transcription STAT3 phosphorylation. Transfection of STAT3 increases DDAH II promoter activity, and alpha-lipoic acid amplifies it. alpha-Lipoic acid-induced increase in DDAH II promoter activity is attenuated in the promoter that has a mutation in the putative STAT3-binding site	711109	
3.5.3.18	up	DDAH-2 protein expression is higher in osteoarthritic cartilage than in normal cartilage	718718	
3.5.3.18	up	during growth on asymmetric dimethyl-L-arginine, induction of the DdaH gene is achieved via the putative enhancer-binding protein PA1196 and the alternative sigma factor RpoN. Both PA1196 and RpoN are essential for the expression of the DdaH gene in response to methylarginines	754016	
3.5.3.18	up	following myocardial infarction, left ventricular DDAH activity is increased to 210% of control	710771	
3.5.3.18	up	in chondrocyte mitochondria extracts, DDAH-2 expression is significantly increased after exposure to IL-1beta	718718	
3.5.3.18	up	resveratrol activates silent information regulator SIRT1 and inhibits upregulates the expression of DDAH2	752652	
3.5.3.18	up	treatment of mice with farnesoid X receptor agonist 3-(2,6-dichlorophenyl)-4-(3'-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole, i.e. GW4064, leads to increased expression of DDAH-1 and cationic amino acid transporter CAT-1 in both liver and kidney	712845