3.4.17.23	down	angiotensin II downregulates ACE2, but increases the expression of vascular endothelial growth factor and type receptor AT1-R, overview	710171	
3.4.17.23	down	central angiotensin II type 1 receptors reduce ACE2 expression/activity in hypertensive mice	708683	
3.4.17.23	down	infection with highly pathogenic avian influenza A H5N1 virus results in downregulation of angiotensin-converting enzyme 2 (ACE2) expression in the lung	732569	
3.4.17.23	down	mechanisms exist by which SARS-CoV-2 induces shedding of ACE2, together with downregulation of ACE2 gene expression	763771	
3.4.17.23	down	mice infected with influenza H7N9 virus downregulate ACE2 protein markedly on day 3 after infection	732911	
3.4.17.23	down	miR-421 (miRNA) downregulates the expression of ACE2 in human cells by interacting with a specific sequence in its 3'-UTR and thereby repressing translation	731675	
3.4.17.23	down	SARS-CoV downregulates ACE2 protein by binding its spike protein, contributing to severe lung injury	753431	
3.4.17.23	down	treatment of A-549 lung epithelial cells with 17-beta-estradiol reduces the cellular mRNA levels of ACE2 and TMPRSS2 mRNA, while not affecting FURIN expression	764554	
3.4.17.23	additional information	ACE2 mRNA and protein expression in murine lung, heart and aorta is not influenced by ibuprofen	764930	
3.4.17.23	additional information	presence of ibuprofen, flurbiprofen, etoricoxib or paracetamol have no effect on ACE2 mRNA/protein expression and activity in the Caco-2 cell model	764930