1.14.99.38	down	porcine reproductive and respiratory syndrome virus infection significantly downregulates the expression of the enzyme in cells	745658	
1.14.99.38	down	the enzyme mRNA expression level is originally low in myelodysplasia/leukemia cell lines. Enzyme knockdown partially protects the cells from decitabine-induced cell death	746440	
1.14.99.38	additional information	enzyme expression is not induced by interferons in human cells and knockdown of STAT-1 has no effect on the induction of the enzyme	745657	
1.14.99.38	up	activation of the innate immune system by TLR ligands induces 25-hydroxycholesterol production which results in suppression of IgA class switching in B cells	727109	
1.14.99.38	up	both IFN-alpha- and IFN-gamma induce the enzyme in bone marrow-derived macrophages	727611	
1.14.99.38	up	exposure to DNA methyltransferase inhibitors and decitabine enhances enzyme mRNA expression in myelodysplasia/leukemia cell lines	746440	
1.14.99.38	up	induction of Ch25h is JAK- and STAT1-dependent, overview	-, 715833	
1.14.99.38	up	induction of CYP3A by pregnenolone-16 alpha-carbonitrile causes accumulation of 25-hydroxycholesterol in cell line AML12 derived from mouse liver, the induction is not suppressed by the addition of desmosterol. Although the transcription of Ch25h is also upregulated by addition of pregnenolone-16 alpha-carbonitrile, the protein level of CH25H is not elevated. Desmosterol does not affect the expression of cellular CYP3A protein, but CH25H protein level is obviously decreased by desmosterol treatment	728088	
1.14.99.38	up	pseudorabies virus infection of porcine alveolar macrophages is attenuated by enzyme overexpression (24 h post infection)	745479	
1.14.99.38	up	the enzyme expression in primary human hepatocytes is primarily and transiently induced by type I interferon. Infection with hepatitis C virus causes up-regulation of the enzyme in vivo	745051