4.4.1.20	down	expression in mast cells is not apparent in healthy subjects	708181	
4.4.1.20	down	hepatic mRNA expression of LTC4S is decreased in presence of NO donor O2-vinyl-1-(pyrrolidin-1-yl)-diazen-1-ium-1,2-diolate, i.e. V-PYRRO/NO. Downregulation may occur via inhibiting NF-kappaB activation independent of IkappaBalpha during hepatic ischemia/reperfusion injury	747243	
4.4.1.20	down	no upregulation by interleukin-4 in the THP-1 cell line	708859	
4.4.1.20	additional information	is not suppressed by pretreatment with the p38 inhibitor	708600	
4.4.1.20	up	LTC4s increases following spared nerve injury, significant increase 3 days after nerve injury and continues at least for 14 days. LTC4s mRNA is expressed constitutively throughout the grey matter and increases after nerve injury in dorsal horn. This increase in LTC4s mRNA mainly occurrs in cells with small nuclei	708600	
4.4.1.20	up	mRNA levels for the three key enzymes/proteins in the biosynthesis of cysteinyl-leukotrienes, 5-lipoxygenase, 5-LO-activating protein, and LTC4 synthase, are significantly increased in the wall of human abdominal aortic aneurysm	716764	
4.4.1.20	up	significantly elevated immunoexpression of LTC4 synthase observed in perennial allergic rhinitis biopsies	708181