3.4.24.B5	down	endothelin-1 (ET-1) downregulates matrix metalloproteinase 15 expression in human first trimester trophoblasts via endothelin receptor type B (ETRB). ET-1 downregulates MMP15 mRNA and protein levels. TNF-alpha enhances ET-1-mediated MMP15 downregulation in primary trophoblasts	
3.4.24.B5	down	inhibition of follicle ovulation, by the inhibitors roscovitine or CDK9-inhibitor II, is accompanied by the suppression of Mmp15 expression in the follicle. Roscovitine treatment of follicles inhibits Pgr binding to the mmp15 promoter region	
3.4.24.B5	additional information	after phosphorylation (by CDK9 and cyclin 1), Pgr becomes a functional transcription factor for mmp15 gene expression	
3.4.24.B5	up	the enzyme is significantly up-regulated in placentas from severe early-onset preeclamptic pregnancies compared to gestationally matched preterm controls	
3.4.24.B5	up	Mmp15 is an luteinizing hormone (LH)-inducible enzyme