3.4.24.B12	down	fibroblast growth factor 2 inhibits ADAMTS-5 expression in isolated aortic smooth muscle cells and blocks the spontaneous release of ADAMTS-generated versican and aggrecan fragments from aortic explants	734180	
3.4.24.B12	down	the enzyme is expressed 2.1fold less in Sertoli cells of individuals with nonobstructive azoospermia than those of control individuals with obstructive azoospermia	755570	
3.4.24.B12	additional information	ADAMTS-5 expression is not regulated by interleukin-1 and tumor necrosis factor-alpha	720093	
3.4.24.B12	up	Adamts5 mRNA is superinduced in Fgf2–/– mice compared with Fgf2+/+ (fibroblast growth factor 2) mice 2 weeks following surgical destabilization of the medial meniscus	707317	
3.4.24.B12	up	ADAMTS5 protein within cartilage increases following injury and with coculture	707277	
3.4.24.B12	up	disruption of chondrocyte hyaluran receptor CD44-hyaluran interactions with hyaluran oligosaccharides induces the transcription of endopeptidases ADAMTS-4 and ADAMTS-5 in a time- and dose-dependent manner	733229	
3.4.24.B12	up	interleukin-1beta+OSM and tumor necrosis factor alpha+ OSM treatments induces a 17fold and 13fold increase in ADAMTS5 gene expression. Relatively little modulation in ADAMTS5 expression is observed in the presence of interleukin-1beta, tumor necrosis factor alpha or OSM alone	719385