3.4.21.46	down	deguelin, a rotenoid of the flavonoid family, significantly down-regulates the expression of VEGF-D both at the mRNA and protein level in VEGF-D transfected LL/2 Lewis lung cells	
3.4.21.46	down	silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis	
3.4.21.46	up	expression of PoDAK increases in kidney, liver, spleen upon infection with viral hemorrhagic septicemia virus or bacterial infection with Streptococcus iniae	
3.4.21.46	up	in lung cancer cell lines, interleukin-7/interleukin-7 receptor increase the expression of VEGF-D and phosphorylation of c-Fos/c-Jun, induce c-Fos and c-Jun heterodimer formation, and enhance c-Fos/c-Jun DNA binding activity to regulate VEGF-D expression	
3.4.21.46	up	overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB	
3.4.21.46	up	after challenged with Aeromonas hydrophila, the enzyme, at both mRNA and protein levels, is upregulated in the kidney, spleen, liver and head-kidney	
3.4.21.46	up	enzyme expression is increased during adipocyte differentiation	
3.4.21.46	up	enzyme gene and protein expression are increased in the dermal layer of skin specimens from aged subjects (more than70 years old), compared to young subjects (younger than 20 years old)	
3.4.21.46	up	the enzyme is immunologically upregulated by lipopolysaccharide (12 h post injection), Streptococcus iniae (12 h post infection), rock bream iridovirus (6-12 h post infection), and poly I:C (6 h post injection) in spleen tissue