2.3.1.298 down enzyme activity is significantly reduced in the testes of acyl-coenzyme A-binding protein-deficient mice 2.3.1.298 up enzyme mRNA expression significantly increases and remains high throughout keratinocyte differentiation 2.3.1.298 up enzyme mRNA increases during keratinocyte differentiation 2.3.1.298 up the enzyme is upregulated first during meiosis and later on in mid-late spermiogenesis, in spermatocytes and in elongated spermatids