2.1.1.63	down	a loss of MGMT expression is noted in 20 cases of 60 total soft tissue sarcomas	703974	
2.1.1.63	down	extensive methylation of MGMT promoter is associated with loss/reduced protein expression, methylation of MGMT promoter region is essential for methylation-induced silencing of this gene	704064	
2.1.1.63	down	interleukin-24 down-regulates O6-methylguanine-DNA methyltransferase in melanoma cells, accumulation of functional p53 is essential for interleukin-24-induced down-regulation of O6-methylguanine-DNA methyltransferase	705661	
2.1.1.63	down	microRNA-603 directly interacts with the 3'-UTR region of enzyme gene and produces a 6fold decrease of both enzyme mRNA and protein upon transfection in glioblastoma cell line in vitro. Downregulation of enzyme expression by microRNA-181d and microRNA-767-3p is due to degradation of the enzyme mRNA. microRNA-221 and microRNA-222 also downregulate the enzyme expression	757010	
2.1.1.63	down	neither short-term (24 h) nor long-term changes (7 weeks) in S-adenosyl-L-methionine/S-adenosylhomocysteine ratio alter global or MGMT promoter methylation, however, experimentally elevated S-adenosylhomocysteine levels significantly decrease MGMT mRNA levels by more than 50%	702153	
2.1.1.63	down	there is a good correlation between the increasing MGMT promoter methylation and decreased MGMT expression, in most patients who has been treated with temozolomide, there is decreased MGMT expression in the post treatment sample when compared to the primary sample	705274	
2.1.1.63	down	treatment with 0.05 mM disulfiram reduces enzyme protein expression	757679	
2.1.1.63	additional information	promoter methylation of O6-methylguanine-DNA-methyltransferase in lung cancer is regulated by p53	703393	
2.1.1.63	up	ependymomas lack MGMT promoter hypermethylation and show high MGMT protein expression	704813	
2.1.1.63	up	MGMT activity is significantly higher in the group with the lowest consumption of vegetables than in the group with the greatest vegetable consumption	703079	
2.1.1.63	up	resistance to alkylating agents such as temozolomide correlates with increased expression of O6-methylguanine-DNA methyltransferase	705661