1.6.3.5	down	gonadotropin-releasing hormone antagonist, cetrorelix, represses renalase expression in mice ovaries and testes	
1.6.3.5	up	knockout of leptin, an effector and modulator of steroid hormones and reproduction, causes a dramatic increase of renalase expression in mice testes	
1.6.3.5	up	renalase expression is significantly increased in cancers of the pancreas, bladder and breast and in melanoma	
1.6.3.5	up	the secretion of renalase in both plasma and urine is increased in patients with chronic kidney disease