1.3.1.72	down	enzyme expression is down-regulated by application of castasterone and brassinolide	765153	
1.3.1.72	down	histone acetylation also regulates DHCR24 expression, with a reduction in DHCR24 transcription correlating with recruitment of acetylated histones H3 and H4 to its promoter	746354	
1.3.1.72	down	the mRNA expression of the enzyme is significantly decreased in the cortical neurons treated with 0.00001 mM 1,25-dihydroxyvitamin D3	764825	
1.3.1.72	down	vascular endothelial cells have the capacity to instruct vascular smooth muscle cells to shut down the expression of the enzyme thereby limiting their cholesterol biosynthesis	763004	
1.3.1.72	additional information	DHCR24 is transcriptionally regulated by sterols via the sterol-regulatory element-binding protein-2 transcription factor	745512	
1.3.1.72	additional information	expression of DHCR24 is mediated by two sterol regulatory elements (SREs) in the promoter of the gene, assisted by two nearby NF-Y binding sites	724443	
1.3.1.72	additional information	the enzyme is regulated by the following transcription factors/proteins: sterol regulatory element binding protein 2, nuclear factor Y (via methylation), specificity protein 1, estrogen receptor, androgen receptor, thyroid hormone receptor, constitutive androstane receptor, and pregnane X receptor. Transcriptional regulation of DHCR24, detailed overview	746354	
1.3.1.72	up	activation of constitutive androstane receptor (CAR) in cultured human hepatocytes increases mRNA levels of mouse Dhcr24 and human DHCR24. A CAR-responsive element is identified in the promoter of human DHCR24	726516	
1.3.1.72	up	activation of constitutive androstane receptor (CAR) in mouse livers increases mRNA levels of mouse Dhcr24 and human DHCR24	726516	
1.3.1.72	up	DHCR24 is overexpressed in hepatitis C virus-related hepatocellular carcinoma specifically induced by hepatitis C virus	746181	
1.3.1.72	up	enzyme mRNA expression level is significantly increased in protein disulfide isomerase A3 siRNA-treated neurons	764825	
1.3.1.72	up	hepatitis C virus induces the DHCR24 overexpression in human hepatocytes	712405	
1.3.1.72	up	the sterol-regulated region is extremely GC rich and lies within a CpG island, a region of DNA with a high G and C content and a high frequency of CpG dinucleotides, which is conserved in mammals. In addition to containing a specificity protein 1 (Sp1) site required for augmentation of DHCR24 in HCV infection, this region is also important in epigenetic regulation of DHCR24. Methylation of this region decreases DHCR24 expression, with pronounced methylation occurring in cell types with low DHCR24 levels. Sex steroids, such as estrogens and androgens, are positive regulators of DHCR24, increasing gene expression via activation of their respective nuclear receptors, estrogen receptor and androgen receptor, overview. Adrenocorticotropic hormone (ACTH) stimulates the enzyme expression in adrenal gland	746354