6.3.4.3 765141 Folate cycle enzyme MTHFD1L confers metabolic advantages in hepatocellular carcinoma J. Clin. Invest. 127 1856-1872 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28394261&form=6&db=m 6.3.4.3 744335 Impact of mutating the key residues of a bifunctional 5,10-methylenetetrahydrofolate dehydrogenase-cyclohydrolase from Escherichia coli on its activities Biochemistry 54 3504-3513 2015 Clostridium perfringens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25988590&form=6&db=m 6.3.4.3 765861 NAD-dependent methylenetetrahydrofolate dehydrogenase inhibits oral squamous cell carcinoma cell proliferation and promotes apoptosis Transl. Cancer Res. 10 1457-1469 2021 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=35116471&form=6&db=m 6.3.4.3 742789 One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia J. Bacteriol. 197 717-726 2015 Clostridium perfringens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448816&form=6&db=m 6.3.4.3 742789 One-carbon metabolic pathway rewiring in Escherichia coli reveals an evolutionary advantage of 10-formyltetrahydrofolate synthetase (Fhs) in survival under hypoxia J. Bacteriol. 197 717-726 2015 Clostridium perfringens DSM 756 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25448816&form=6&db=m 6.3.4.3 743250 Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli Microbiology 162 145-155 2016 Clostridium perfringens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26531681&form=6&db=m 6.3.4.3 743250 Physiological role of FolD (methylenetetrahydrofolate dehydrogenase), FchA (methenyltetrahydrofolate cyclohydrolase) and Fhs (formyltetrahydrofolate synthetase) from Clostridium perfringens in a heterologous model of Escherichia coli Microbiology 162 145-155 2016 Clostridium perfringens DSM 756 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26531681&form=6&db=m 6.3.4.3 1503 10-Formyltetrahydrofolate synthetase. Evidence for a conformational change in the enzyme upon binding of tetrahydropteroylpolyglutamates J. Biol. Chem. 262 12519-12525 1987 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3497925&form=6&db=m 6.3.4.3 660866 A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma Biochem. Biophys. Res. Commun. 315 204-211 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15013446&form=6&db=m 6.3.4.3 727607 A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development Hum. Mol. Genet. 22 3705-3719 2013 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23704330&form=6&db=m