4.4.1.20 747181 Development of smart cell-free and cell-based assay systems for investigation of leukotriene C4 synthase activity and evaluation of inhibitors Biochim. Biophys. Acta 1861 1605-1613 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27477678&form=6&db=m 4.4.1.20 748662 Microsomal glutathione transferase 2 modulates LTC4 synthesis and ROS production in Apostichopus japonicus Mol. Immunol. 91 114-122 2017 Apostichopus japonicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28892748&form=6&db=m 4.4.1.20 748212 Phosphorylation of leukotriene C4 synthase at serine 36 impairs catalytic activity J. Biol. Chem. 291 18410-18418 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27365393&form=6&db=m 4.4.1.20 748456 Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase J. Pharmacol. Exp. Ther. 355 108-116 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26283693&form=6&db=m 4.4.1.20 747243 V-PYRRO/NO downregulates mRNA expression levels of leukotriene C4 synthase during hepatic ischemia reperfusion injury in rats via inhibition of the nuclear factor-kappaB activation pathway Biomed. Rep. 4 112-116 2016 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26870346&form=6&db=m 4.4.1.20 644484 14,15-dehydroleukotriene A4: a specific substrate for leukotriene C4 synthase Biochem. J. 328 225-229 1997 Homo sapiens - 4.4.1.20 665246 A novel single-nucleotide substitution, Glu 4 Lys, in the leukotriene C4 synthase gene associated with allergic diseases Int. J. Mol. Med. 16 827-831 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16211251&form=6&db=m 4.4.1.20 715569 Arginine 104 is a key catalytic residue in leukotriene C4 synthase J. Biol. Chem. 285 40771-40776 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20980252&form=6&db=m 4.4.1.20 644494 Characterization of leukotriene C4 synthetase in mouse peritoneal exudate cells Biochim. Biophys. Acta 959 386-398 1988 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833315&form=6&db=m 4.4.1.20 644502 Conversion of leukotrienes A4 to C4 in cell-free systems Biochem. Biophys. Res. Commun. 134 85-92 1986 Cavia porcellus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3004446&form=6&db=m 4.4.1.20 644502 Conversion of leukotrienes A4 to C4 in cell-free systems Biochem. Biophys. Res. Commun. 134 85-92 1986 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3004446&form=6&db=m 4.4.1.20 644502 Conversion of leukotrienes A4 to C4 in cell-free systems Biochem. Biophys. Res. Commun. 134 85-92 1986 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3004446&form=6&db=m 4.4.1.20 682093 Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis Nature 448 609-612 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17632548&form=6&db=m 4.4.1.20 730061 Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism J. Biol. Chem. 289 5199-5207 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24366866&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Oryctolagus cuniculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Equus caballus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Ovis aries http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 no activity in Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 644501 Demonstration of leukotriene-C4 synthase in platelets and species distribution of the enzyme activity Eur. J. Biochem. 251 227-235 1998 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9492288&form=6&db=m 4.4.1.20 702043 Distinct parts of leukotriene C(4) synthase interact with 5-lipoxygenase and 5-lipoxygenase activating protein Biochem. Biophys. Res. Commun. 381 518-522 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19233132&form=6&db=m 4.4.1.20 695266 Enhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharide-induced rat fulminant hepatic failure model World J. Gastroenterol. 14 2748-2756 2008 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18461660&form=6&db=m 4.4.1.20 692276 Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy FASEB J. 22 3525-3536 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18591367&form=6&db=m 4.4.1.20 678958 Familial aggregation of aspirin-induced urticaria and leukotriene C synthase allelic variant Br. J. Dermatol. 154 256-260 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16433794&form=6&db=m 4.4.1.20 644487 Formation of murine macrophage-derived 5-oxo-7-glutathionyl-8,11,14-eicosatrienoic acid (FOG7) is catalyzed by leukotriene C4 synthase J. Biol. Chem. 277 7037-7043 2002 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11748223&form=6&db=m 4.4.1.20 695153 Genetic variation in members of the leukotriene biosynthesis pathway confer an increased risk of ischemic stroke: a replication study in two independent populations Stroke 39 1109-1114 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18323512&form=6&db=m 4.4.1.20 694966 High-level expression, purification, and crystallization of recombinant rat leukotriene C4 synthase from the yeast Pichia pastoris Protein Expr. Purif. 60 1-6 2008 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18440824&form=6&db=m 4.4.1.20 666465 Highly selective localization of leukotriene C4 synthase in hypothalamic and extrahypothalamic vasopressin systems of mouse brain Neuroscience 131 683-689 2005 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15730873&form=6&db=m 4.4.1.20 679295 Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4 Clin. Exp. Allergy 37 880-892 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17517102&form=6&db=m 4.4.1.20 666938 Human leukotriene C4 synthase at 4.5.ANG. resolution in projection Structure 12 2009-2014 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15530365&form=6&db=m 4.4.1.20 644493 Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells J. Biol. Chem. 267 17849-17857 1992 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517222&form=6&db=m 4.4.1.20 644493 Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells J. Biol. Chem. 267 17849-17857 1992 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1517222&form=6&db=m 4.4.1.20 644488 Human mast cells express two leukotriene C4 synthase isoenzymes and the CysLT1 receptor Biochim. Biophys. Acta 1583 53-62 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12069849&form=6&db=m 4.4.1.20 681027 Identification of regions of leukotriene C4 synthase which direct the enzyme to its nuclear envelope localization J. Cell. Biochem. 98 1517-1527 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16552728&form=6&db=m 4.4.1.20 716764 Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm Proc. Natl. Acad. Sci. USA 107 21093-21097 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21078989&form=6&db=m 4.4.1.20 665809 Induction of leukotriene C4 synthase after the differentiation of rat basophilic leukemia cells with retinoic acid and a low dose of actinomycin D and its suppression with methylprednisolone J. Cell. Physiol. 196 154-164 2003 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12767051&form=6&db=m 4.4.1.20 665848 Inhibition of 5-lipoxygenase and leukotriene C4 synthase in human blood cells by thymoquinone J. Enzyme Inhib. Med. Chem. 19 431-436 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15648658&form=6&db=m 4.4.1.20 644500 Isolation and characterization of leukotriene C4 synthetase of rat basophilic leukemia cells Proc. Natl. Acad. Sci. USA 82 8399-8403 1985 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3866231&form=6&db=m 4.4.1.20 644489 Kinetic mechanism of glutathione conjugation to leukotriene A4 by leukotriene C4 synthase Biochim. Biophys. Acta 1391 157-168 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9554994&form=6&db=m 4.4.1.20 644490 Leukotriene C synthase in mouse mastocytoma cells. An enzyme distinct from cytosolic and microsomal glutathione transferases Biochem. J. 250 713-718 1988 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3134007&form=6&db=m 4.4.1.20 666794 Leukotriene C4 synthase Prostaglandins Leukot. Essent. Fatty Acids 69 111-116 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12895593&form=6&db=m 4.4.1.20 709560 Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals J. Mol. Cell. Cardiol. 46 579-586 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19280718&form=6&db=m 4.4.1.20 644505 Leukotriene C4 synthase from rat basophilic leukemia cell microsomes Methods Enzymol. 163 353-357 1988 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3237082&form=6&db=m 4.4.1.20 664161 Leukotriene C4 synthase homo-oligomers detected in living cells by bioluminescence resonance energy transfer Biochim. Biophys. Acta 1633 90-95 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12880868&form=6&db=m 4.4.1.20 677985 Leukotriene C4 synthase promoter driven expression of GFP reveals cell specificity Biochem. Biophys. Res. Commun. 366 80-85 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18053799&form=6&db=m 4.4.1.20 644499 Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes Prostaglandins Other Lipid Mediat. 68-69 511-520 2002 Cavia porcellus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432940&form=6&db=m 4.4.1.20 644499 Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes Prostaglandins Other Lipid Mediat. 68-69 511-520 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432940&form=6&db=m 4.4.1.20 644499 Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes Prostaglandins Other Lipid Mediat. 68-69 511-520 2002 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432940&form=6&db=m 4.4.1.20 644499 Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes Prostaglandins Other Lipid Mediat. 68-69 511-520 2002 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12432940&form=6&db=m 4.4.1.20 644507 Leukotriene C4 synthase: characterization in mouse mastocytoma cells Methods Enzymol. 187 306-312 1990 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172733&form=6&db=m 4.4.1.20 708600 Leukotriene synthases and the receptors induced by peripheral nerve injury in the spinal cord contribute to the generation of neuropathic pain Glia 58 599-610 2010 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19908283&form=6&db=m 4.4.1.20 665347 Leukotriene synthesis is increased by transcriptional up-regulation of 5-lipoxygenase, leukotriene A4 hydrolase, and leukotriene C4 synthase in asthmatic children J. Asthma 40 147-154 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12765316&form=6&db=m 4.4.1.20 709128 Location, location, location: compartmentalization of early events in leukotriene biosynthesis J. Biol. Chem. 285 25109-25114 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20507998&form=6&db=m 4.4.1.20 644485 LTC4 synthase: Enzymology, biochemistry, and molecular characterization Clin. Rev. Allergy Immunol. 17 133-152 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10436863&form=6&db=m 4.4.1.20 644491 Membrane localization and topology of leukotriene C4 synthase J. Biol. Chem. 277 28902-28908 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12023288&form=6&db=m 4.4.1.20 664566 Microsomal glutathione S-transferases: selective up-regulation of leukotriene C4 synthase during lipopolysaccharide-induced pyresis Cell. Mol. Life Sci. 62 87-94 2005 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15619010&form=6&db=m 4.4.1.20 708859 Modulation by aspirin of nuclear phospho-signal transducer and activator of transcription 6 expression: Possible role in therapeutic benefit associated with aspirin desensitization J. Allergy Clin. Immunol. 124 724-730 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19767084&form=6&db=m 4.4.1.20 663826 Molecular and catalytic properties of three rat leukotriene C4 synthase homologs Biochem. Biophys. Res. Commun. 312 271-276 2003 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14637132&form=6&db=m 4.4.1.20 644508 Molecular cloning, expression and characterization of mouse leukotriene C4 synthase Eur. J. Biochem. 238 606-612 1996 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8706658&form=6&db=m 4.4.1.20 644508 Molecular cloning, expression and characterization of mouse leukotriene C4 synthase Eur. J. Biochem. 238 606-612 1996 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8706658&form=6&db=m 4.4.1.20 708181 Nasal mucosal expression of the leukotriene and prostanoid pathways in seasonal and perennial allergic rhinitis Clin. Exp. Allergy 39 820-828 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19364335&form=6&db=m 4.4.1.20 716061 Novel mutations in leukotriene C4 synthase and risk of cardiovascular disease based on genotypes from 50,000 individuals J. Thromb. Haemost. 8 1694-1701 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20456754&form=6&db=m 4.4.1.20 644498 On the nature of leukotriene C4 synthase in human platelets Arch. Biochem. Biophys. 294 70-74 1992 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1312812&form=6&db=m 4.4.1.20 690662 Promotor polymorphisms in leukotriene C4 synthase and risk of ischemic cerebrovascular disease Arterioscler. Thromb. Vasc. Biol. 28 990-996 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18276912&form=6&db=m 4.4.1.20 692199 Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepatotoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway Eur. J. Pharmacol. 603 98-107 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19087874&form=6&db=m 4.4.1.20 644495 Protein-protein interaction affinity chromatography of leukotriene C4 synthase Protein Expr. Purif. 6 352-356 1995 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663172&form=6&db=m 4.4.1.20 644495 Protein-protein interaction affinity chromatography of leukotriene C4 synthase Protein Expr. Purif. 6 352-356 1995 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7663172&form=6&db=m 4.4.1.20 644506 Purification and properties of leukotriene C4 synthase from guinea pig lung microsomes Methods Enzymol. 187 335-337 1990 Cavia porcellus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2172737&form=6&db=m 4.4.1.20 644503 Purification of human leukotriene C4 synthase Proc. Natl. Acad. Sci. USA 89 11603-11606 1992 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1454853&form=6&db=m 4.4.1.20 644504 Purification of human leukotriene C4 synthase from dimethylsulfoxide-differentiated U937 cells Eur. J. Biochem. 209 725-734 1992 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1425677&form=6&db=m 4.4.1.20 644492 Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits Proc. Natl. Acad. Sci. USA 90 2015-2019 1993 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8446623&form=6&db=m 4.4.1.20 644510 Renal leukotriene C4 synthase: characterization, partial purification and alterations in experimental glomerulonephritis Biochim. Biophys. Acta 1254 207-215 1995 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7827126&form=6&db=m 4.4.1.20 678098 Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats Biochem. Pharmacol. 73 724-735 2007 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17194456&form=6&db=m 4.4.1.20 678098 Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats Biochem. Pharmacol. 73 724-735 2007 Rattus norvegicus Sprague-Dawley http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17194456&form=6&db=m 4.4.1.20 644509 Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase Arch. Biochem. Biophys. 230 455-465 1984 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6324687&form=6&db=m 4.4.1.20 644496 Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4 Biochim. Biophys. Acta 959 305-315 1988 Cavia porcellus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833313&form=6&db=m 4.4.1.20 644496 Solubilization and partial purification of leukotriene C4 synthase from guinea-pig lung: a microsomal enzyme with high specificity towards 5,6-epoxide leukotriene A4 Biochim. Biophys. Acta 959 305-315 1988 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2833313&form=6&db=m 4.4.1.20 682094 Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase Nature 448 613-616 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17632546&form=6&db=m 4.4.1.20 730788 Structure and inhibition of mouse leukotriene C4 synthase PLoS ONE 9 e96763 2014 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24810165&form=6&db=m 4.4.1.20 709410 The A-444C polymorphism in the leukotriene C4 synthase gene is associated with aspirin-induced urticaria J. Investig. Allergol. Clin. Immunol. 19 375-382 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19862937&form=6&db=m 4.4.1.20 644486 The biochemical, molecular, and genomic aspects of leukotriene C4 synthase Proc. Assoc. Am. Phys. 111 537-546 1999 Cavia porcellus - 4.4.1.20 644486 The biochemical, molecular, and genomic aspects of leukotriene C4 synthase Proc. Assoc. Am. Phys. 111 537-546 1999 Homo sapiens - 4.4.1.20 644486 The biochemical, molecular, and genomic aspects of leukotriene C4 synthase Proc. Assoc. Am. Phys. 111 537-546 1999 Mus musculus - 4.4.1.20 715600 The catalytic architecture of leukotriene C4 synthase with two arginine residues J. Biol. Chem. 286 16392-16401 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21454538&form=6&db=m 4.4.1.20 730555 The catalytic formation of leukotriene C4: a critical step in inflammatory processes Phys. Chem. Chem. Phys. 16 16284-16289 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24974917&form=6&db=m 4.4.1.20 666717 The membrane organization of leukotriene synthesis Proc. Natl. Acad. Sci. USA 101 6587-6592 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15084748&form=6&db=m 4.4.1.20 677457 TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes Am. J. Physiol. 292 L215-L222 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980379&form=6&db=m 4.4.1.20 677480 TNF-alpha downregulates the leukotriene C4 synthase gene in mononuclear phagocytes Am. J. Physiol. Lung Cell Mol. Physiol. 292 L215-L222 2007 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16980379&form=6&db=m 4.4.1.20 644497 Two step purification of human and murine leukotriene C4 synthase Biochim. Biophys. Acta 1256 257-261 1995 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7766706&form=6&db=m 4.4.1.20 644497 Two step purification of human and murine leukotriene C4 synthase Biochim. Biophys. Acta 1256 257-261 1995 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7766706&form=6&db=m 4.4.1.20 709717 Two-dimensional crystallization conditions of human leukotriene C4 synthase requiring adjustment of a particularly large combination of specific parameters J. Struct. Biol. 169 450-454 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19903529&form=6&db=m 4.4.1.20 714941 Zymosan suppresses leukotriene C4 synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors FASEB J. 25 1417-1427 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21228223&form=6&db=m