3.4.24.B10 755405 ADAM12 and ADAM17 are essential molecules for hypoxia-induced impairment of neural vascular barrier function Sci. Rep. 5 12796 2015 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26242473&form=6&db=m 3.4.24.B10 754704 ADAM12 is a novel regulator of tumor angiogenesis via STAT3 signaling Mol. Cancer Res. 15 1608-1622 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28765266&form=6&db=m 3.4.24.B10 755485 ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells Sci. Rep. 7 9687 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28852196&form=6&db=m 3.4.24.B10 753925 Identification of ADAM12 as a novel basigin sheddase Int. J. Mol. Sci. 20 E1957 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31013576&form=6&db=m 3.4.24.B10 754703 Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer Mol. Cancer 16 32 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28148288&form=6&db=m 3.4.24.B10 755025 The Elsevier Trophoblast Research Award Lecture Importance of metzincin proteases in trophoblast biology and placental development a focus on ADAM12 Placenta 36 Suppl 1 S11-S19 2015 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25589360&form=6&db=m 3.4.24.B10 712898 A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma J. Surg. Oncol. 100 267-272 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19544357&form=6&db=m 3.4.24.B10 668153 A role for ADAM12 in breast tumor progression and stromal cell apoptosis Cancer Res. 65 4754-4761 2005 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15930294&form=6&db=m 3.4.24.B10 733079 A substrate-optimized electrophoretic mobility shift assay for ADAM12 Anal. Biochem. 452 34-42 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24534253&form=6&db=m 3.4.24.B10 651290 Activation of ADAM 12 protease by copper FEBS Lett. 506 65-68 2001 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11591372&form=6&db=m 3.4.24.B10 669952 ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes J. Neurosci. Res. 75 353-360 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743448&form=6&db=m 3.4.24.B10 669952 ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes J. Neurosci. Res. 75 353-360 2004 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14743448&form=6&db=m 3.4.24.B10 669293 ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage J. Biol. Chem. 279 51323-51330 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15381692&form=6&db=m 3.4.24.B10 652002 ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3 J. Biol. Chem. 275 18574-18580 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10849447&form=6&db=m 3.4.24.B10 649557 ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3 Biochem. Biophys. Res. Commun. 278 511-515 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11095942&form=6&db=m 3.4.24.B10 677883 ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage Arthritis Rheum. 58 778-789 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18311789&form=6&db=m 3.4.24.B10 713386 ADAM-12 stability in first trimester maternal serum Prenat. Diagn. 30 555-560 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20509156&form=6&db=m 3.4.24.B10 670208 ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation Mol. Biol. Cell 16 861-870 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15574885&form=6&db=m 3.4.24.B10 669528 ADAM12 is a four-leafed clover: the excised prodomain remains bound to the mature enzyme J. Biol. Chem. 281 9418-9422 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16455653&form=6&db=m 3.4.24.B10 711642 ADAM12 is expressed by astrocytes during experimental demyelination Brain Res. 1326 1-14 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20176000&form=6&db=m 3.4.24.B10 670445 ADAM12 is highly expressed in carcinoma-associated stroma and is required for mouse prostate tumor progression Oncogene 25 5462-5466 2006 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16607276&form=6&db=m 3.4.24.B10 667133 ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor Am. J. Pathol. 165 1743-1753 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15509542&form=6&db=m 3.4.24.B10 711938 ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity Exp. Cell Res. 316 55-67 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19769962&form=6&db=m 3.4.24.B10 711706 Adam12 plays a role during uterine decidualization in mice Cell Tissue Res. 338 413-421 2009 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19841944&form=6&db=m 3.4.24.B10 719935 ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis J. Biol. Chem. 286 20758-20768 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21493715&form=6&db=m 3.4.24.B10 734812 ADAM12-cleaved ephrin-A1 contributes to lung metastasis Oncogene 33 2179-2190 2014 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23686306&form=6&db=m 3.4.24.B10 733623 ADAM12-directed ectodomain shedding of E-cadherin potentiates trophoblast fusion Cell Death Differ. 22 1970-1984 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25909890&form=6&db=m 3.4.24.B10 668620 ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins FEBS Lett. 579 5589-5595 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16213489&form=6&db=m 3.4.24.B10 669565 ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation J. Bone Miner. Res. 21 1288-1296 2006 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16869727&form=6&db=m 3.4.24.B10 734620 ADAMTS-12: a multifaced metalloproteinase in arthritis and inflammation Mediators Inflamm. 2014 649718 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24876675&form=6&db=m 3.4.24.B10 670683 Amyloid-beta neurotoxicity is mediated by FISH adapter protein and ADAM12 metalloprotease activity Proc. Natl. Acad. Sci. USA 102 3058-3063 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15710903&form=6&db=m 3.4.24.B10 651993 Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion J. Biol. Chem. 275 13933-13939 2000 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10788519&form=6&db=m 3.4.24.B10 680219 Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein Int. J. Cancer 122 2634-2640 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18241035&form=6&db=m 3.4.24.B10 678344 Catalytic properties of ADAM12 and its domain deletion mutants Biochemistry 47 537-547 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18081311&form=6&db=m 3.4.24.B10 680191 Cellular roles of ADAM12 in health and disease Int. J. Biochem. Cell Biol. 40 1685-1702 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18342566&form=6&db=m 3.4.24.B10 680191 Cellular roles of ADAM12 in health and disease Int. J. Biochem. Cell Biol. 40 1685-1702 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18342566&form=6&db=m 3.4.24.B10 669346 Cooperation of the metalloprotease, disintegrin, and cysteine-rich domains of ADAM12 during inhibition of myogenic differentiation J. Biol. Chem. 280 23475-23483 2005 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15849365&form=6&db=m 3.4.24.B10 652137 Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85alpha activates phosphatidylinositol 3-kinase in C2C12 cells J. Biol. Chem. 276 24466-24472 2001 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11313349&form=6&db=m 3.4.24.B10 735053 Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12 PLoS ONE 7 e37628 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22662180&form=6&db=m 3.4.24.B10 711818 Hair-cycle dependent differential expression of ADAM 10 and ADAM 12: An immunohistochemical analysis in human hair follicles in situ Dermato-endocrinology 1 46-53 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20046589&form=6&db=m 3.4.24.B10 668501 Hierarchy of ADAM12 binding to integrins in tumor cells Exp. Cell Res. 309 438-450 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061220&form=6&db=m 3.4.24.B10 651886 Human ADAM 12 (meltrin alpha) is an active metalloprotease J. Biol. Chem. 273 16993-16997 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9642263&form=6&db=m 3.4.24.B10 734657 Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival Mol. Biol. Cell 23 3461-3472 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22767580&form=6&db=m 3.4.24.B10 668496 Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1 Exp. Cell Res. 298 28-37 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15242759&form=6&db=m 3.4.24.B10 649712 Metalloprotease-disintegrin ADAM 12 interacts with alpha-actinin-1 Biochem. J. 357 353-361 2001 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11439084&form=6&db=m 3.4.24.B10 713177 Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort Osteoarthritis Cartilage 17 1093-1098 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19268722&form=6&db=m 3.4.24.B10 719334 Molecular characterization and expression analysis of ADAM12 during chicken embryonic development Dev. Growth Differ. 52 757-769 2010 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21158755&form=6&db=m 3.4.24.B10 679271 Molecular profiling of ADAM12 in human bladder cancer Clin. Cancer Res. 12 7359-7368 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17189408&form=6&db=m 3.4.24.B10 652478 PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor J. Biol. Chem. 278 46029-46034 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12952982&form=6&db=m 3.4.24.B10 720822 Regulated expression of ADAMTS-12 in human trophoblastic cells: A role for ADAMTS-12 in epithelial cell invasion? PLoS ONE 6 e18473 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21494557&form=6&db=m 3.4.24.B10 651920 Regulation of human ADAM 12 protease by the prodomain. Evidence for a functional cysteine switch J. Biol. Chem. 274 13427-13433 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10224107&form=6&db=m 3.4.24.B10 652051 RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction J. Biol. Chem. 275 34922-34930 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10944520&form=6&db=m 3.4.24.B10 690386 Role of a disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium Am. J. Respir. Cell Mol. Biol. 41 449-458 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19213876&form=6&db=m 3.4.24.B10 668419 Role of meltrin {alpha} (ADAM12) in obesity induced by high-fat diet Endocrinology 146 1752-1763 2005 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15637293&form=6&db=m 3.4.24.B10 653221 Role of metalloprotease disintegrin ADAM12 in determination of quiescent reserve cells during myogenic differentiation in vitro Mol. Cell. Biol. 23 6725-6738 2003 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12972593&form=6&db=m 3.4.24.B10 711148 Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2) Biochem. J. 430 79-86 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20533908&form=6&db=m 3.4.24.B10 667947 Structure-based virtual screening and biological evaluation of potent and selective ADAM12 inhibitors Bioorg. Med. Chem. Lett. 14 6071-6074 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15546732&form=6&db=m 3.4.24.B10 681003 The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor J. Cell Biol. 178 201-208 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17620406&form=6&db=m 3.4.24.B10 668997 The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer Int. J. Oncol. 26 17-24 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15586220&form=6&db=m 3.4.24.B10 734873 The Elsevier trophoblast research award lecture: Importance of metzincin proteases in trophoblast biology and placental development: A focus on ADAM12 Placenta 36 S11-S19 2015 Mus musculus - 3.4.24.B10 653225 The expression of the ADAMs proteases in prostate cancer cell lines and their regulation by dihydrotestosterone Mol. Cell. Endocrinol. 167 11-21 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11000516&form=6&db=m 3.4.24.B10 735109 The metalloprotease ADAM12 regulates the effector function of human Th17 cells PLoS ONE 8 e81146 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24363794&form=6&db=m 3.4.24.B10 712445 The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12 J. Biol. Chem. 285 21969-21977 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20457602&form=6&db=m 3.4.24.B10 677449 Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice Am. J. Pathol. 171 1599-1607 2007 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17982130&form=6&db=m