3.2.1.166 753249 Design, synthesis, and evaluation of heparan sulfate mimicking glycopolymers for inhibiting heparanase activity Chem. Commun. (Camb.) 53 9163-9166 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28766595&form=6&db=m 3.2.1.166 753154 Development of new methods for determining the heparanase enzymatic activity Carbohydr. Res. 412 66-70 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26062789&form=6&db=m 3.2.1.166 754818 Functional and structural characterization of a heparanase Nat. Chem. Biol. 11 955-957 2015 Burkholderia pseudomallei http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26565989&form=6&db=m 3.2.1.166 759360 Heparan sulfate biosynthetic system is inhibited in human glioma due to EXT1/2 and HS6ST1/2 down-regulation Int. J. Mol. Sci. 18 2301 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29104277&form=6&db=m 3.2.1.166 753404 Heparanase from basic research to therapeutic applications in cancer and inflammation Drug Resist. Updat. 29 54-75 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27912844&form=6&db=m 3.2.1.166 755125 Heparanase activates antithrombin through the binding to its heparin binding site PLoS ONE 11 e0157834 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27322195&form=6&db=m 3.2.1.166 755259 Heparanase is required for activation and function of macrophages Proc. Natl. Acad. Sci. USA 113 E7808-E7817 2016 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27849593&form=6&db=m 3.2.1.166 754394 Novel symmetrical benzazolyl derivatives endowed with potent anti-heparanase activity J. Med. Chem. 61 10834-10859 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30412404&form=6&db=m 3.2.1.166 754873 Structural characterization of human heparanase reveals insights into substrate recognition Nat. Struct. Mol. Biol. 22 1016-1022 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26575439&form=6&db=m 3.2.1.166 731254 1H NMR spectroscopic studies establish that heparanase is a retaining glycosidase Biochem. Biophys. Res. Commun. 443 185-188 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24291708&form=6&db=m 3.2.1.166 714936 A novel human heparanase splice variant, T5, endowed with protumorigenic characteristics FASEB J. 24 1239-1248 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20007507&form=6&db=m 3.2.1.166 694846 Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant Proc. Natl. Acad. Sci. USA 102 15161-15166 2005 Nannospalax galili http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204381&form=6&db=m 3.2.1.166 694846 Adaptive evolution of heparanase in hypoxia-tolerant Spalax: gene cloning and identification of a unique splice variant Proc. Natl. Acad. Sci. USA 102 15161-15166 2005 Nannospalax judaei http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16204381&form=6&db=m 3.2.1.166 732546 Astragalus embranaceus extract activates immune response in macrophages via heparanase Molecules 17 7232-7240 2012 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22695229&form=6&db=m 3.2.1.166 731586 Bacterial expression and functional reconstitution of human heparanase Carbohydr. Res. 389 72-77 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24656445&form=6&db=m 3.2.1.166 690801 Biochemical characterization of the active heterodimer form of human heparanase (Hpa1) protein expressed in insect cells Biochem. J. 373 423-435 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12713442&form=6&db=m 3.2.1.166 693728 Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats J. Neurochem. 105 34-45 2008 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17996027&form=6&db=m 3.2.1.166 731425 Chemical shift assignments and secondary structure of the surrogate domain for drug discovery studies of human heparanase Biomol. NMR Assign. 9 15-19 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24395156&form=6&db=m 3.2.1.166 694956 Cloning, expression, and purification of mouse heparanase Protein Expr. Purif. 26 425-431 2002 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12460766&form=6&db=m 3.2.1.166 731884 Computational analyses of the catalytic and heparin-binding sites and their interactions with glycosaminoglycans in glycoside hydrolase family 79 endo-D-glucuronidase (heparanase) Glycobiology 22 35-55 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21746763&form=6&db=m 3.2.1.166 701675 Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening Anal. Biochem. 396 112-116 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19748475&form=6&db=m 3.2.1.166 731648 Development of novel inhibitors specific for human heparanase-1 Chem. Lett. 42 797-798 2013 Homo sapiens - 3.2.1.166 692954 Expression pattern and secretion of human and chicken heparanase are determined by their signal peptide sequence J. Biol. Chem. 276 29178-29187 2001 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11387326&form=6&db=m 3.2.1.166 714922 Focus on molecules: Heparanase Exp. Eye Res. 91 476-477 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20478306&form=6&db=m 3.2.1.166 715536 Heparanase 2 interacts with heparan sulfate with high affinity and inhibits heparanase activity J. Biol. Chem. 285 28010-28019 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20576607&form=6&db=m 3.2.1.166 714108 Heparanase enhances nerve growth factor induced PC12 cell neuritogenesis via the p38 MAPK pathway Biochem. J. 440 273-282 2011 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21831044&form=6&db=m 3.2.1.166 731350 Heparanase expression and localization in different types of human lung cancer Biochim. Biophys. Acta 1840 2599-2608 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24747732&form=6&db=m 3.2.1.166 705306 Heparanase in primary human osteoblast J. Orthop. Res. 28 1315-1322 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20309870&form=6&db=m 3.2.1.166 731355 Heparanase is a key player in renal fibrosis by regulating TGF-beta expression and activity Biochim. Biophys. Acta 1843 2122-2128 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24937189&form=6&db=m 3.2.1.166 731626 Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice Cell. Mol. Life Sci. 71 2347-2357 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24169805&form=6&db=m 3.2.1.166 731626 Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice Cell. Mol. Life Sci. 71 2347-2357 2014 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24169805&form=6&db=m 3.2.1.166 731626 Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice Cell. Mol. Life Sci. 71 2347-2357 2014 Mus musculus BALB/c http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24169805&form=6&db=m 3.2.1.166 715656 Heparanase plays a dual role in driving hepatocyte growth factor (HGF) signaling by enhancing HGF expression and activity J. Biol. Chem. 286 6490-6499 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21131364&form=6&db=m 3.2.1.166 715737 Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice J. Clin. Invest. 121 1709-1721 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21490396&form=6&db=m 3.2.1.166 732087 Heparanase regulates secretion, composition, and function of tumor cell-derived exosomes J. Biol. Chem. 288 10093-10099 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23430739&form=6&db=m 3.2.1.166 716243 Heparanase upregulates Th2 cytokines, ameliorating experimental autoimmune encephalitis Mol. Immunol. 47 1890-1898 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20399501&form=6&db=m 3.2.1.166 692520 Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans Glycobiology 11 91R-98R 2001 Cricetulus griseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445547&form=6&db=m 3.2.1.166 692520 Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans Glycobiology 11 91R-98R 2001 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11445547&form=6&db=m 3.2.1.166 704045 Histidine-rich glycoprotein binds heparanase and regulates its enzymatic activity and cell surface interactions Int. J. Biochem. Cell Biol. 42 1507-1516 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20561914&form=6&db=m 3.2.1.166 731468 Hit identification of novel heparanase inhibitors by structure- and ligand-based approaches Bioorg. Med. Chem. 21 1944-1951 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23415087&form=6&db=m 3.2.1.166 693933 Human heparanase nuclear localization and enzymatic activity Lab. Invest. 84 535-544 2004 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034597&form=6&db=m 3.2.1.166 693933 Human heparanase nuclear localization and enzymatic activity Lab. Invest. 84 535-544 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15034597&form=6&db=m 3.2.1.166 692946 Human heparanase. Purification, characterization, cloning, and expression J. Biol. Chem. 274 24153-24160 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10446189&form=6&db=m 3.2.1.166 692975 Identification and characterization of heparin/heparan sulfate binding domains of the endoglycosidase heparanase J. Biol. Chem. 280 20457-20466 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15760902&form=6&db=m 3.2.1.166 690874 Identification of active-site residues of the pro-metastatic endoglycosidase heparanase Biochemistry 39 15659-15667 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11123890&form=6&db=m 3.2.1.166 692095 Induction of heparanase in bovine granulosa cells by luteinizing hormone: possible role during the ovulatory process Endocrinology 150 413-421 2009 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18818292&form=6&db=m 3.2.1.166 715155 Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase Immunol. Cell Biol. 90 159-167 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21606942&form=6&db=m 3.2.1.166 732437 Involvement of heparanase in atherosclerosis and other vessel wall pathologies Matrix Biol. 32 241-251 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499530&form=6&db=m 3.2.1.166 694315 Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis Nat. Med. 5 793-802 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10395325&form=6&db=m 3.2.1.166 693320 Mammalian heparanase: what is the message? J. Cell. Mol. Med. 11 427-452 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17635638&form=6&db=m 3.2.1.166 731820 Mechanisms of heparanase inhibition by the heparan sulfate mimetic PG545 and three structural analogues FEBS Open Bio 3 346-351 2013 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24251094&form=6&db=m 3.2.1.166 695085 Molecular cloning and characterisation of heparanase mRNA in the porcine placenta throughout gestation Reprod. Fertil. Dev. 21 757-772 2009 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19567219&form=6&db=m 3.2.1.166 732435 Multi-faceted substrate specificity of heparanase Matrix Biol. 32 223-227 2013 Mammalia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499529&form=6&db=m 3.2.1.166 691602 Oligomannurarate sulfate, a novel heparanase inhibitor simultaneously targeting basic fibroblast growth factor, combats tumor angiogenesis and metastasis Cancer Res. 66 8779-8787 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16951194&form=6&db=m 3.2.1.166 690796 Partial purification of heparanase activities in Chinese hamster ovary cells: evidence for multiple intracellular heparanases Biochem. J. 336 191-200 1998 Cricetulus griseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9806900&form=6&db=m 3.2.1.166 692967 Processing of macromolecular heparin by heparanase J. Biol. Chem. 278 35152-35158 2003 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12837765&form=6&db=m 3.2.1.166 692947 Processing of the human heparanase precursor and evidence that the active enzyme is a heterodimer J. Biol. Chem. 274 29587-29590 1999 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10514423&form=6&db=m 3.2.1.166 714960 Proteoglycans in health and disease: new concepts for heparanase function in tumor progression and metastasis FEBS J. 277 3890-3903 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20840586&form=6&db=m 3.2.1.166 693502 Purification and characterization of the endoglycosidase heparanase 1 from human plantar stratum corneum: a key enzyme in epidermal physiology? J. Invest. Dermatol. 117 1266-1273 2001 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11710943&form=6&db=m 3.2.1.166 714343 Regulation of heparanase by albumin and advanced glycation end products in proximal tubular cells Biochim. Biophys. Acta 1813 1475-1482 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21600934&form=6&db=m 3.2.1.166 716701 Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice PLoS ONE 6 e18370 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21483695&form=6&db=m 3.2.1.166 706907 Stable knockdown of heparanase expression in gastric cancer cells in vitro World J. Gastroenterol. 15 5442-5448 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19916174&form=6&db=m 3.2.1.166 692964 Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence J. Biol. Chem. 277 42488-42495 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12213822&form=6&db=m 3.2.1.166 692943 Substrate specificity of heparanases from human hepatoma and platelets J. Biol. Chem. 273 18770-18777 1998 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9668050&form=6&db=m 3.2.1.166 732954 The endoglycosidase heparanase enters the nucleus of T lymphocytes and modulates H3 methylation at actively transcribed genes via the interplay with key chromatin modifying enzymes Transcription 3 130-145 2012 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22771948&form=6&db=m 3.2.1.166 692699 The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy Invest. New Drugs 28 276-283 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19357810&form=6&db=m 3.2.1.166 731867 The role of heparanase and sulfatases in the modification of heparan sulfate proteoglycans within the tumour microenvironment and opportunities for novel cancer therapeutics Front. Oncol. 4 195 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25105093&form=6&db=m 3.2.1.166 704661 Unraveling the specificity of heparanase utilizing synthetic substrates J. Biol. Chem. 285 14504-14513 2010 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20181948&form=6&db=m 3.2.1.166 732436 Versatile role of heparanase in inflammation Matrix Biol. 32 234-240 2013 Mammalia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23499528&form=6&db=m