2.7.1.150 761922 Fluconazole-induced actin cytoskeleton remodeling requires phosphatidylinositol 3-phosphate 5-kinase in the pathogenic yeast Candida glabrata Mol. Microbiol. 110 425-443 2018 [Candida] glabrata http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30137648&form=6&db=m 2.7.1.150 762289 Inhibition of PIKfyve kinase prevents infection by Zaire ebolavirus and SARS-CoV-2 Proc. Natl. Acad. Sci. USA 117 20803-20813 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32764148&form=6&db=m 2.7.1.150 762218 Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control PLoS ONE 12 e0172740 2017 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273166&form=6&db=m 2.7.1.150 762218 Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control PLoS ONE 12 e0172740 2017 Schizosaccharomyces pombe ATCC 24843 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273166&form=6&db=m 2.7.1.150 762218 Ste12/Fab1 phosphatidylinositol-3-phosphate 5-kinase is required for nitrogen-regulated mitotic commitment and cell size control PLoS ONE 12 e0172740 2017 Schizosaccharomyces pombe 972 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28273166&form=6&db=m 2.7.1.150 761580 The amino acid transporter SLC-36.1 cooperates with PtdIns3P 5-kinase to control phagocytic lysosome reformation J. Cell Biol. 218 2619-2637 2019 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31235480&form=6&db=m 2.7.1.150 673833 Cloning and subcellular localization of a human phosphatidylinositol 3-phosphate 5-kinase, PIKfyve/Fab1 Gene 371 34-41 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16448788&form=6&db=m 2.7.1.150 738465 Distinct requirements for vacuolar protein sorting 34 downstream effector phosphatidylinositol 3-phosphate 5-kinase in podocytes versus proximal tubular cells J. Am. Soc. Nephrol. 27 2702-2719 2016 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26825532&form=6&db=m 2.7.1.150 675887 Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors Mol. Biol. Cell 17 3989-4001 2006 Drosophila sp. (in: flies) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16837550&form=6&db=m 2.7.1.150 675014 Fab1p and AP-1 are required for trafficking of endogenously ubiquitylated cargoes to the vacuole lumen in S. cerevisiae J. Cell Sci. 119 4225-4234 2006 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003107&form=6&db=m 2.7.1.150 723139 Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1 Mol. Biol. Cell 23 2955-2962 2012 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22696681&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Drosophila melanogaster http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Oryza sativa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 660790 Phosphatidylinositol 3,5-bisphosphate: metabolism and function Arch. Biochem. Biophys. 407 143-151 2002 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12413484&form=6&db=m 2.7.1.150 737640 Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle Biochem. J. 455 195-206 2013 Didelphis sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23905686&form=6&db=m 2.7.1.150 737640 Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle Biochem. J. 455 195-206 2013 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23905686&form=6&db=m 2.7.1.150 393217 Phosphatidylinositol 3-phosphate 5-kinase is required for the cellular response to nutritional starvation and mating pheromone signals in Schizosaccharomyces pombe Genes Cells 7 199-215 2002 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11895483&form=6&db=m 2.7.1.150 739357 Phosphatidylinositol 3-phosphate 5-kinase, FAB1/PIKfyve kinase mediates endosome maturation to establish endosome-cortical microtubule interaction in Arabidopsis Plant Physiol. 169 1961-1974 2015 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26353760&form=6&db=m 2.7.1.150 393216 Regulation of fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by vac7 protein and fig4, a polyphosphoinositide phosphatase family member Mol. Biol. Cell 13 1238-1251 2002 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11950935&form=6&db=m 2.7.1.150 722001 Regulation of the glutamate transporter EAAT4 by PIKfyve Cell. Physiol. Biochem. 25 187-194 2010 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20110679&form=6&db=m 2.7.1.150 671803 Regulation of the Na(+), glucose cotransporter by PIKfyve and the serum and glucocorticoid inducible kinase SGK1 Biochem. Biophys. Res. Commun. 359 843-847 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17570343&form=6&db=m 2.7.1.150 675013 The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport J. Cell Sci. 119 3944-3957 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16954148&form=6&db=m 2.7.1.150 675885 The phosphoinositide kinase PIKfyve/Fab1p regulates terminal lysosome maturation in Caenorhabditis elegans Mol. Biol. Cell 17 3062-3074 2006 Caenorhabditis elegans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16801682&form=6&db=m 2.7.1.150 393215 The stress-activated phosphatidylinositol 3-phosphate 5-kinase Fab1p is essential for vacuole function in S. cerevisiae Curr. Biol. 8 1219-1222 1998 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9811604&form=6&db=m 2.7.1.150 675001 The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover J. Cell Biol. 172 693-704 2006 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16492811&form=6&db=m 2.7.1.150 661530 Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body Curr. Biol. 12 885-893 2002 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12062051&form=6&db=m 2.7.1.150 661530 Vac14 controls PtdIns(3,5)P2 synthesis and Fab1-dependent protein trafficking to the multivesicular body Curr. Biol. 12 885-893 2002 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12062051&form=6&db=m