2.1.1.14 755889 Fungal cobalamin-independent methionine synthase Insights from the model organism, Neurospora crassa Arch. Biochem. Biophys. 590 125-137 2016 Neurospora crassa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26657067&form=6&db=m 2.1.1.14 757179 Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae J. Biol. Chem. 292 14730-14746 2017 Komagataella pastoris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28701466&form=6&db=m 2.1.1.14 757334 Methionine synthase 1 provides methionine for activation of the GLR3.5 Ca2+ channel and regulation of germination in Arabidopsis J. Exp. Bot. 71 178-187 2020 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31563952&form=6&db=m 2.1.1.14 758312 Cobalamin-independent methionine synthase distribution and influence on vitamin B12 growth requirements in marine diatoms Protist 168 32-47 2017 Fragilariopsis cylindrus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27951467&form=6&db=m 2.1.1.14 757345 RNase E/G-dependent degradation of metE mRNA, encoding methionine synthase, in Corynebacterium glutamicum J. Gen. Appl. Microbiol. 65 47-52 2019 Corynebacterium glutamicum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29984738&form=6&db=m 2.1.1.14 757345 RNase E/G-dependent degradation of metE mRNA, encoding methionine synthase, in Corynebacterium glutamicum J. Gen. Appl. Microbiol. 65 47-52 2019 Corynebacterium glutamicum ATCC 31831 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29984738&form=6&db=m 2.1.1.14 755895 Insights into the role of methionine synthase in the universal 13C depletion in O- and N-methyl groups of natural products Arch. Biochem. Biophys. 635 60-65 2017 synthetic construct http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29074162&form=6&db=m 2.1.1.14 757428 The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation J. Mol. Biol. 427 901-909 2015 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545590&form=6&db=m 2.1.1.14 441331 Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties Eur. J. Biochem. 230 1053-1058 1995 Catharanthus roseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7601135&form=6&db=m 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Klebsiella aerogenes - 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Saccharomyces cerevisiae - 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Auxenochlorella pyrenoidosa - 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Escherichia coli - 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Neurospora crassa - 2.1.1.14 441326 N5-Methyltetrahydrofolate-homocysteine methyltransferases The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 9 121-165 1973 Salmonella enterica subsp. enterica serovar Typhimurium - 2.1.1.14 441332 Cobalamin-independent methionine synthase from Escherichia coli: A zinc metalloenzyme Biochemistry 35 12228-12234 1996 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8823155&form=6&db=m 2.1.1.14 660332 Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli PLoS Biol. 2 1738-1753 2004 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15502870&form=6&db=m 2.1.1.14 441330 Regulation of methionine biosythesis in Neurospora crassa Arch. Biochem. Biophys. 168 219-229 1975 Neurospora crassa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=124550&form=6&db=m 2.1.1.14 441334 The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants Biochem. Biophys. Res. Commun. 36 228-234 1969 Phaseolus vulgaris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5799642&form=6&db=m 2.1.1.14 441217 L-Selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases Bioorg. Med. Chem. Lett. 10 2471-2475 2000 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11078203&form=6&db=m 2.1.1.14 660333 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication PLoS Biol. 3 254-265 2005 Thermotoga maritima - 2.1.1.14 441333 Cloning and characterization of a cDNA encoding a cobalamin-independent methionine synthase from potato (Solanum tuberosum L.) Plant Mol. Biol. 48 255-265 2002 Solanum tuberosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11855727&form=6&db=m 2.1.1.14 706748 Isolation and expression analysis of a cobalamin-independent methionine synthase gene from the parasitic plant Orobanche ramosa Sci. Hortic. 116 337-341 2008 Phelipanche ramosa - 2.1.1.14 704294 Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli J. Bacteriol. 191 3407-3410 2009 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19286805&form=6&db=m 2.1.1.14 441322 Sulphur metabolism. F. Enzymes involved in the synthesis of methionine Methods Plant Biochem. 3 361-369 1990 Daucus carota - 2.1.1.14 441322 Sulphur metabolism. F. Enzymes involved in the synthesis of methionine Methods Plant Biochem. 3 361-369 1990 Hordeum vulgare - 2.1.1.14 441322 Sulphur metabolism. F. Enzymes involved in the synthesis of methionine Methods Plant Biochem. 3 361-369 1990 Phaseolus sp. - 2.1.1.14 441322 Sulphur metabolism. F. Enzymes involved in the synthesis of methionine Methods Plant Biochem. 3 361-369 1990 Pisum sativum - 2.1.1.14 441322 Sulphur metabolism. F. Enzymes involved in the synthesis of methionine Methods Plant Biochem. 3 361-369 1990 Spinacia oleracea - 2.1.1.14 657437 Cloning and identification of methionine synthase gene from Pichia pastoris Acta Biochim. Biophys. Sin. 37 371-378 2005 Komagataella pastoris http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15944751&form=6&db=m 2.1.1.14 441328 Methionine synthesis (Yeast) Methods Enzymol. 17B 388-392 1971 Saccharomyces cerevisiae - 2.1.1.14 441323 Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase J. Biol. Chem. 245 390-401 1970 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4904482&form=6&db=m 2.1.1.14 659400 Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate J. Biol. Chem. 279 44235-44238 2004 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15326182&form=6&db=m 2.1.1.14 441329 Cloning and expression of the metE gene in Escherichia coli Arch. Biochem. Biophys. 239 467-474 1985 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2988449&form=6&db=m 2.1.1.14 441172 Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli Biochem. J. 92 497-504 1964 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5319972&form=6&db=m 2.1.1.14 672156 Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase Biochemistry 45 5083-5091 2006 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618097&form=6&db=m 2.1.1.14 672156 Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase Biochemistry 45 5083-5091 2006 Escherichia coli pJG816 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618097&form=6&db=m 2.1.1.14 672157 Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase Biochemistry 45 5092-5102 2006 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16618098&form=6&db=m 2.1.1.14 671587 Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae Arch. Biochem. Biophys. 441 56-63 2005 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083849&form=6&db=m 2.1.1.14 671587 Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae Arch. Biochem. Biophys. 441 56-63 2005 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16083849&form=6&db=m 2.1.1.14 441175 Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem Biochemistry 31 6045-6056 1992 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1339288&form=6&db=m 2.1.1.14 720259 Crystal structures of cobalamin-independent methionine synthase (MetE) from Streptococcus mutans: a dynamic zinc-inversion model J. Mol. Biol. 412 688-697 2011 Streptococcus mutans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21840320&form=6&db=m 2.1.1.14 441337 Plant methionine synthase: new insights into properties and expression Biol. Chem. 381 695-703 2000 Catharanthus roseus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11030427&form=6&db=m 2.1.1.14 733170 Evolved cobalamin-independent methionine synthase (MetE) improves the acetate and thermal tolerance of Escherichia coli Appl. Environ. Microbiol. 79 7905-7915 2013 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24123739&form=6&db=m 2.1.1.14 733198 Proteomic insights into metabolic adaptation to deletion of metE in Saccharopolyspora spinosa Appl. Microbiol. Biotechnol. 99 8629-8641 2015 Saccharopolyspora spinosa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26266753&form=6&db=m 2.1.1.14 734490 The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation J. Mol. Biol. 427 901-909 2015 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545590&form=6&db=m 2.1.1.14 734490 The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation J. Mol. Biol. 427 901-909 2015 Candida albicans ATCC MYA-2876 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25545590&form=6&db=m 2.1.1.14 720398 Mechanism of methionine synthase overexpression in chaperonin-depleted Escherichia coli Microbiology 158 917-924 2012 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22262097&form=6&db=m 2.1.1.14 671122 Preparation, crystallization and preliminary X-ray analysis of the methionine synthase (MetE) from Streptococcus mutans Acta Crystallogr. Sect. F 62 984-985 2006 Streptococcus mutans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17012790&form=6&db=m 2.1.1.14 441218 characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy Biochemistry 40 987-993 2001 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11170420&form=6&db=m 2.1.1.14 441327 Folic acid and the methylation of homocysteine by Bacillus subtilis Biochem. J. 126 993-1004 1972 Bacillus subtilis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4627401&form=6&db=m 2.1.1.14 735002 Methionine biosynthesis is essential for infection in the rice blast fungus Magnaporthe oryzae PLoS ONE 10 e0111108 2015 Pyricularia oryzae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25856162&form=6&db=m 2.1.1.14 676741 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication PLoS Biol. 3 e31 2005 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630480&form=6&db=m 2.1.1.14 676741 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication PLoS Biol. 3 e31 2005 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630480&form=6&db=m 2.1.1.14 676741 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication PLoS Biol. 3 e31 2005 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630480&form=6&db=m 2.1.1.14 676741 Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication PLoS Biol. 3 e31 2005 Thermotoga maritima http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15630480&form=6&db=m