1.4.4.2 765473 A novel mutation in the glycine decarboxylase gene in patient with non-ketotic hyperglycinemia Neurosciences (Riyadh) 22 131-133 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28416785&form=6&db=m 1.4.4.2 764702 Downregulation of glycine decarboxylase enhanced cofilin-mediated migration in hepatocellular carcinoma cells Free Radic. Biol. Med. 120 1-12 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29524606&form=6&db=m 1.4.4.2 765869 Glycine decarboxylase and HIF-1alpha expression are negative prognostic factors in primary resected early-stage non-small cell lung cancer Virchows Arch. 470 323-330 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28062918&form=6&db=m 1.4.4.2 765486 Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity Oncogene 38 7504-7520 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31444411&form=6&db=m 1.4.4.2 741906 Glycine decarboxylase is an unusual amino acid decarboxylase involved in tumorigenesis Biochemistry 53 947-956 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24467211&form=6&db=m 1.4.4.2 765323 Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control Metab. Eng. 53 35-47 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30779965&form=6&db=m 1.4.4.2 765452 mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis Nat. Commun. 12 4227 2021 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34244482&form=6&db=m 1.4.4.2 743023 Mutation analysis of glycine decarboxylase, aminomethyltransferase and glycine cleavage system protein-H genes in 13 unrelated families with glycine encephalopathy J. Hum. Genet. 59 593-597 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25231368&form=6&db=m 1.4.4.2 762597 Obesity increases hepatic glycine dehydrogenase and aminomethyltransferase expression while dietary glycine supplementation reduces white adipose tissue in Zucker diabetic fatty rats Amino Acids 52 1413-1423 2020 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33057941&form=6&db=m 1.4.4.2 743266 Plasmodium berghei glycine cleavage system T-protein is non-essential for parasite survival in vertebrate and invertebrate hosts Mol. Biochem. Parasitol. 197 50-55 2014 no activity in Plasmodium berghei http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25454081&form=6&db=m 1.4.4.2 763473 Serum glycine dehydrogenase is associated with increased risk of lung cancer and promotes malignant transformation by regulating DNA methyltransferases expression Mol. Med. Rep. 18 2293-2299 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29956770&form=6&db=m 1.4.4.2 392000 Activation of glycine decarboxylase in pea leaf mitochondria by ATP Arch. Biochem. Biophys. 320 250-256 1995 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7625831&form=6&db=m 1.4.4.2 697916 Alternative splicing produces an H-protein with better substrate properties for the P-protein of glycine decarboxylase FEBS J. 276 6985-6991 2009 Flaveria trinervia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19860829&form=6&db=m 1.4.4.2 391981 Amino acid sequence of the phosphopyridoxyl peptide from P-protein of the chicken liver glycine cleavage system Biochem. Biophys. Res. Commun. 149 621-627 1987 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3426593&form=6&db=m 1.4.4.2 654089 Coexpression, purification, crystallization and preliminary X-ray characterization of glycine decarboxylase (P-protein) of the glycine-cleavage system from Thermus thermophilus HB8 Acta Crystallogr. Sect. D 59 554-557 2003 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595724&form=6&db=m 1.4.4.2 654089 Coexpression, purification, crystallization and preliminary X-ray characterization of glycine decarboxylase (P-protein) of the glycine-cleavage system from Thermus thermophilus HB8 Acta Crystallogr. Sect. D 59 554-557 2003 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12595724&form=6&db=m 1.4.4.2 719865 Crystal structure of aminomethyltransferase in complex with dihydrolipoyl-H-protein of the glycine cleavage system: implications for recognition of lipoyl protein substrate, disease-related mutations, and reaction mechanism J. Biol. Chem. 285 18684-18692 2010 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20375021&form=6&db=m 1.4.4.2 710748 Crystallization and preliminary X-ray diffraction analyses of the homodimeric glycine decarboxylase (P-protein) from the cyanobacterium Synechocystis sp. PCC 6803 Acta Crystallogr. Sect. F 66 187-191 2010 Synechocystis sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20124719&form=6&db=m 1.4.4.2 689575 Deletion of glycine decarboxylase in Arabidopsis is lethal under nonphotorespiratory conditions Plant Physiol. 144 1328-1335 2007 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17496108&form=6&db=m 1.4.4.2 656820 Detection of mutations in the glycine decarboxylase gene in patients with nonketotic hyperglycinaemia Mol. Genet. Metab. 84 167-171 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15670722&form=6&db=m 1.4.4.2 391996 Effects of tetrahydrofolate polyglutamates on the kinetic parameters of serine hydroxymethyltransferase and glycine decarboxylase from pea leaf mitochondria Biochem. J. 292 425-430 1993 Pisum sativum - 1.4.4.2 698096 Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications Gene 432 7-18 2009 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19084582&form=6&db=m 1.4.4.2 724197 Glycine cleavage enzyme complex: molecular cloning and expression of the H-protein cDNA from cultured human skin fibroblasts Biochem. Cell Biol. 89 299-307 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21539457&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Gottschalkia acidurici http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Escherichia coli http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Peptoclostridium acidaminophilum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 706478 Glycine cleavage system: reaction mechanism, physiological significance, and hyperglycinemia Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 84 246-263 2008 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18941301&form=6&db=m 1.4.4.2 724693 Glycine decarboxylase cleaves a malignant metabolic path to promote tumor initiation Cancer Cell 21 143-145 2012 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22340586&form=6&db=m 1.4.4.2 725016 Glycine decarboxylase controls photosynthesis and plant growth FEBS Lett. 586 3692-3697 2012 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22982108&form=6&db=m 1.4.4.2 391979 Glycine decarboxylase multienzyme complex. Purification and partial characterization from pea leaf mitochondria J. Biol. Chem. 261 2214-2221 1986 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3080433&form=6&db=m 1.4.4.2 676168 Glycine decarboxylase mutations: a distinctive phenotype of nonketotic hyperglycinemia in adults Neurology 64 1255-1257 2005 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15824356&form=6&db=m 1.4.4.2 391998 Glycine decarboxylase: protein chemistry and molecular biology of the major protein in leaf mitochondria J. Bioenerg. Biomembr. 27 407-414 1995 C3-plants http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595976&form=6&db=m 1.4.4.2 391998 Glycine decarboxylase: protein chemistry and molecular biology of the major protein in leaf mitochondria J. Bioenerg. Biomembr. 27 407-414 1995 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8595976&form=6&db=m 1.4.4.2 391993 Glycine metabolism by rat liver mitochondria. Reconstruction of the reversible glycine cleavage system with partially purified protein components Arch. Biochem. Biophys. 164 624-633 1974 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4460882&form=6&db=m 1.4.4.2 391991 Glycine metabolism. I. Properties of the system catalyzing the exchange of bicarbonate with the carboxyl group of glycine in Peptococcus glycinophilus J. Biol. Chem. 241 197-205 1966 Parvimonas micra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5901047&form=6&db=m 1.4.4.2 391992 Glycine metabolism. II. Kinetic and optical studies on the glycine decarboxylase system from Peptococcus glycinophilus J. Biol. Chem. 241 206-209 1966 Parvimonas micra http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=5901048&form=6&db=m 1.4.4.2 391983 Immunocytochemical localization of proteins P1, P2, P3 of glycine decarboxylase and of the selenoprotein PA of glycine reductase, all involved in anaerobic glycine metabolism of Eubacterium acidaminophilum Arch. Microbiol. 152 182-188 1989 Peptoclostridium acidaminophilum - 1.4.4.2 391997 Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria Biochem. J. 302 223-228 1994 Pisum sativum - 1.4.4.2 660325 Interaction between photorespiration and respiration in transgenic potato plants with antisense reduction in glycine decarboxylase Planta 222 130-140 2005 Solanum tuberosum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15809865&form=6&db=m 1.4.4.2 391986 Mechanism of the glycine cleavage reaction. Steady state kinetic studies of the P-protein-catalyzed reaction J. Biol. Chem. 258 8156-8162 1983 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6863283&form=6&db=m 1.4.4.2 391985 Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation Arch. Biochem. Biophys. 251 121-127 1986 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098173&form=6&db=m 1.4.4.2 391985 Mechanism of the glycine cleavage reaction: retention of C-2 hydrogens of glycine on the intermediate attached to H-protein and evidence for the inability of serine hydroxymethyltransferase to catalyze the glycine decarboxylation Arch. Biochem. Biophys. 251 121-127 1986 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3098173&form=6&db=m 1.4.4.2 391994 Mechanism of the reversible glycine cleavage reaction in Arthrobacter globiformis. I. Purification and function of protein components required for the reaction J. Biochem. 75 1113-1127 1974 Arthrobacter globiformis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4414614&form=6&db=m 1.4.4.2 688637 Mitochondria from leaf mesophyll cells of C(4) plants are deficient in the H protein of glycine decarboxylase complex J. Plant Physiol. 165 1061-1069 2008 Zea mays http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17945380&form=6&db=m 1.4.4.2 656807 Novel mutations in the P-protein (glycine decarboxylase) gene in patients with glycine encephalopathy (non-ketotic hyperglycinemia) Mol. Genet. Metab. 76 243-249 2002 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12126939&form=6&db=m 1.4.4.2 686720 Properties of recombinant glycine decarboxylase P- and H-protein subunits from the cyanobacterium Synechocystis sp. strain PCC 6803 FEBS Lett. 581 1297-1301 2007 Synechocystis sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17349627&form=6&db=m 1.4.4.2 673411 Proteins of the glycine decarboxylase complex in the hydrogenosome of Trichomonas vaginalis Eukaryot. Cell 5 2062-2071 2006 Trichomonas vaginalis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17158739&form=6&db=m 1.4.4.2 391980 Purification and partial characterization of the glycine decarboxylase multienzyme complex from Eubacterium acidaminophilum J. Bacteriol. 171 2209-2215 1989 Peptoclostridium acidaminophilum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2495273&form=6&db=m 1.4.4.2 391990 Purification and properties of glycine decarboxylase, a component of the glycine cleavage system, from rat liver mitochondria and immunochemical comparison of this enzyme from various sources J. Biochem. 88 1193-1199 1980 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6778858&form=6&db=m 1.4.4.2 713311 Regulation of plant glycine decarboxylase by s-nitrosylation and glutathionylation Plant Physiol. 152 1514-1528 2010 Arabidopsis thaliana http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20089767&form=6&db=m 1.4.4.2 391984 Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase Biochem. J. 255 169-178 1988 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3143355&form=6&db=m 1.4.4.2 391982 Spatial and temporal influences on the cell-specific distribution of glycine decarboxylase in leaves of wheat (Triticum aestivum L.) and pea (Pisum sativum L.) Plant Physiol. 91 1219-1225 1989 Pisum sativum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16667135&form=6&db=m 1.4.4.2 391982 Spatial and temporal influences on the cell-specific distribution of glycine decarboxylase in leaves of wheat (Triticum aestivum L.) and pea (Pisum sativum L.) Plant Physiol. 91 1219-1225 1989 Triticum aestivum http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16667135&form=6&db=m 1.4.4.2 391995 Specific induction by glycine of the gene for the P-subunit of glycine decarboxylase from Saccharomyces cerevisiae Mol. Microbiol. 19 611-623 1996 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8830251&form=6&db=m 1.4.4.2 655343 Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia EMBO J. 24 1523-1536 2005 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15791207&form=6&db=m 1.4.4.2 655343 Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia EMBO J. 24 1523-1536 2005 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15791207&form=6&db=m 1.4.4.2 689605 The gene for the P-subunit of glycine decarboxylase from the C4 species Flaveria trinervia: analysis of transcriptional control in transgenic Flaveria bidentis (C4) and Arabidopsis (C3) Plant Physiol. 146 1773-1785 2008 Flaveria trinervia http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18305210&form=6&db=m 1.4.4.2 676396 The glycine decarboxylase complex is not essential for the cyanobacterium Synechocystis sp. strain PCC 6803 Plant Biol. 7 15-22 2005 Synechocystis sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15666206&form=6&db=m 1.4.4.2 676396 The glycine decarboxylase complex is not essential for the cyanobacterium Synechocystis sp. strain PCC 6803 Plant Biol. 7 15-22 2005 Synechocystis sp. PCC 6803 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15666206&form=6&db=m 1.4.4.2 688072 The glycine decarboxylase complex multienzyme family in Populus J. Exp. Bot. 58 1761-1770 2007 Populus tremuloides http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17355947&form=6&db=m 1.4.4.2 391999 The glycine decarboxylase system in higher plant mitochondria: structure, function and biogenesis Biochem. Soc. Trans. 22 184-188 1994 C3-plants http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8206222&form=6&db=m 1.4.4.2 391989 The mitochondrial glycine cleavage system. Functional association of glycine decarboxylase and aminomethyl carrier protein J. Biol. Chem. 255 11671-11676 1980 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7440563&form=6&db=m 1.4.4.2 391978 The mitochondrial glycine cleavage system. Purification and properties of glycine decarboxylase from chicken liver mitochondria J. Biol. Chem. 255 11664-11670 1980 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7440562&form=6&db=m 1.4.4.2 391988 The mitochondrial glycine cleavage system: differential inhibition by divalent cations of glycine synthesis and glycine decarboxylation in the glycine-CO2 exchange J. Biochem. 92 937-944 1982 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6815172&form=6&db=m 1.4.4.2 391987 The mitochondrial glycine cleavage system: inactivation of glycine decarboxylase as a side reaction of the glycine decarboxylation in the presence of aminomethyl carrier protein J. Biochem. 92 1489-1498 1982 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7153213&form=6&db=m 1.4.4.2 676615 The plant-like C2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria Plant Physiol. 142 333-342 2006 Synechocystis sp. http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877700&form=6&db=m 1.4.4.2 676615 The plant-like C2 glycolate cycle and the bacterial-like glycerate pathway cooperate in phosphoglycolate metabolism in cyanobacteria Plant Physiol. 142 333-342 2006 Synechocystis sp. PCC 6803 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16877700&form=6&db=m 1.4.4.2 725115 Transcriptionally and phylogenetically analyzing the P protein gene of glycine decarboxylase for understanding the evolution of C3-C4 species in Brassicaceae Hortic. Environ. Biotechnol. 52 427-434 2011 Brassica napus -