1.14.99.20 744612 Influence of proton pump inhibitors and VKORC1 mutations on CYP2C9-mediated dose requirements of vitamin K antagonist therapy a pilot study Br. J. Haematol. 167 547-553 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25142093&form=6&db=m 1.14.99.20 672089 Bronsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation Biochemistry 45 13239-13248 2006 Leptospira interrogans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17073445&form=6&db=m 1.14.99.20 438300 Changes in phylloquinone epoxidase activity related to prothrombin synthesis and microsomal clotting activity in the rat Biochem. J. 140 435-441 1974 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4155625&form=6&db=m 1.14.99.20 438311 Developmental changes of vitamin K epoxidase and reductase activities involved in the vitamin K cycle in human liver Early Hum. Dev. 57 15-23 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10690708&form=6&db=m 1.14.99.20 438308 Mutagenesis of vitamin K-dependent carboxylase demonstrates a carboxyl terminus-mediated interaction with vitamin K hydroquinone J. Biol. Chem. 270 5305-5311 1995 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7890642&form=6&db=m 1.14.99.20 438306 Oxygen dependence of vitamin K-dependent carboxylase and vitamin K epoxidase FEBS Lett. 200 71-75 1986 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3699166&form=6&db=m 1.14.99.20 438309 Profactor IX propeptide and glutamate substrate binding sites on the vitamin K-dependent carboxylase identified by site-directed mutagenesis J. Biol. Chem. 271 17837-17844 1996 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8663364&form=6&db=m 1.14.99.20 438310 Propeptide and glutamate-containing substrates bound to the vitamin K-dependent carboxylase convert its vitamin K epoxidase function from an inactive to an active state Proc. Natl. Acad. Sci. USA 94 9069-9074 1997 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9256436&form=6&db=m 1.14.99.20 438302 The inhibition of vitamin K-dependent carboxylase by cyanide FEBS Lett. 137 253-256 1982 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6277693&form=6&db=m 1.14.99.20 674485 The vitamin K-dependent carboxylase has been acquired by Leptospira pathogens and shows altered activity that suggests a role other than protein carboxylation J. Biol. Chem. 280 34870-34877 2005 Leptospira interrogans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16061481&form=6&db=m 1.14.99.20 438301 Vitamin K epoxidase: dependence of epoxidase activity on substrates of the vitamin K-dependent carboxylation reaction FEBS Lett. 109 267-270 1980 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7353649&form=6&db=m 1.14.99.20 438304 Vitamin K epoxidase: properties and relationship to prothrombin synthesis Biochemistry 16 3856-3863 1977 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=901759&form=6&db=m 1.14.99.20 438307 Vitamin K-dependent carboxylase: affinity purification from bovine liver by using a synthetic propeptide containing the gamma-carboxylation recognition site Proc. Natl. Acad. Sci. USA 86 6893-6897 1989 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2780546&form=6&db=m 1.14.99.20 438303 Vitamin K-dependent carboxylase: evidence for a hydroperoxide intermediate in the reaction Proc. Natl. Acad. Sci. USA 75 5413-5416 1978 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=281691&form=6&db=m 1.14.99.20 438305 Vitamin K-dependent carboxylase: evidence for cofractionation of carboxylase and epoxidase activities, and for carboxylation of a high-molecular-weight microsomal protein Arch. Biochem. Biophys. 214 155-163 1982 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7081994&form=6&db=m