1.14.11.16 765330 Active site characterization and activity of the human aspartyl (asparaginyl) beta-hydroxylase Metallomics 13 mfab056 2021 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34543426&form=6&db=m 1.14.11.16 743376 Aspartate beta-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma Oncogenesis 6 e362 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28714949&form=6&db=m 1.14.11.16 743377 Aspartate beta-hydroxylase expression promotes a malignant pancreatic cellular phenotype Oncotarget 6 1231-1248 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25483102&form=6&db=m 1.14.11.16 742626 Aspartate beta-hydroxylase modulates cellular senescence through glycogen synthase kinase 3beta in hepatocellular carcinoma Hepatology 63 1213-1226 2016 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26683595&form=6&db=m 1.14.11.16 764397 Aspartate beta-hydroxylase promotes cholangiocarcinoma progression by modulating RB1 phosphorylation Cancer Lett. 429 1-10 2018 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=29733964&form=6&db=m 1.14.11.16 764407 Aspartate beta-hydroxylase targeting in castration-resistant prostate cancer modulates the NOTCH/HIF1alpha/GSK3beta crosstalk Carcinogenesis 41 1246-1252 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32525968&form=6&db=m 1.14.11.16 743882 Aspartate-beta-hydroxylase induces epitope-specific T cell responses in hepatocellular carcinoma Vaccine 33 1256-1266 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25629522&form=6&db=m 1.14.11.16 765784 Aspartate/asparagine-beta-hydroxylase a high-throughput mass spectrometric assay for discovery of small molecule inhibitors Sci. Rep. 10 8650 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32457455&form=6&db=m 1.14.11.16 765446 Aspartate/asparagine-beta-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern Nat. Commun. 10 4910 2019 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=31659163&form=6&db=m 1.14.11.16 765316 Characterization of the relationship between the expression of aspartate beta-hydroxylase and the pathological characteristics of breast cancer Med. Sci. Monit. 26 e926752 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33380715&form=6&db=m 1.14.11.16 765190 Construction and characterization of adenovirus vectors encoding aspartate-beta-hydroxylase to preliminary application in immunotherapy of hepatocellular carcinoma J. Immunol. Res. 2018 9832467 2018 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=30116759&form=6&db=m 1.14.11.16 742666 Inhibition of human natural killer cell functional activity by human aspartyl alpha-hydroxylase Int. Immunopharmacol. 23 452-459 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25281391&form=6&db=m 1.14.11.16 765071 Kinetic parameters of human aspartate/asparagine-beta-hydroxylase suggest that it has a possible function in oxygen sensing J. Biol. Chem. 295 7826-7838 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32107312&form=6&db=m 1.14.11.16 743379 Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma Oncotarget 8 12983-13002 2017 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28099905&form=6&db=m 1.14.11.16 743130 Regulation of aspartyl-(asparaginyl)-?-hydroxylase protein expression and function by phosphorylation in hepatocellular carcinoma cells J. Nat. Sci. 1 e84 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26029741&form=6&db=m 1.14.11.16 742226 Research progress of aspartyl-(asparaginyl) beta-hydroxylase in tumors Cancer Res. Clinic 27 280-282 2015 Homo sapiens - 1.14.11.16 764282 Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-beta-hydroxylase Bioorg. Med. Chem. 28 115675 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=33069066&form=6&db=m 1.14.11.16 764470 Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-beta-hydroxylase Chem. Sci. 12 1327-1342 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=34163896&form=6&db=m 1.14.11.16 764503 Synthesis of novel pyridine-carboxylates as small-molecule inhibitors of human aspartate/asparagine-beta-hydroxylase ChemMedChem 15 1139-1149 2020 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32330361&form=6&db=m 1.14.11.16 742572 The aspartyl (asparaginyl) beta-hydroxylase in carcinomas Front. Biosci. 20 902-909 2015 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=25553486&form=6&db=m 1.14.11.16 439256 A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases Proc. Natl. Acad. Sci. USA 91 7227-7231 1994 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8041771&form=6&db=m 1.14.11.16 699589 Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function J. Mol. Biol. 392 994-1006 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19646994&form=6&db=m 1.14.11.16 687592 Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor J. Biol. Chem. 282 24027-24038 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17573339&form=6&db=m 1.14.11.16 687592 Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor J. Biol. Chem. 282 24027-24038 2007 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17573339&form=6&db=m 1.14.11.16 439251 Aspartyl beta-hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin J. Biol. Chem. 275 39543-39554 2000 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10956665&form=6&db=m 1.14.11.16 439260 Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX Proc. Natl. Acad. Sci. USA 86 3609-3613 1989 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2726737&form=6&db=m 1.14.11.16 439260 Aspartyl beta-hydroxylase: in vitro hydroxylation of a synthetic peptide based on the structure of the first growth factor-like domain of human factor IX Proc. Natl. Acad. Sci. USA 86 3609-3613 1989 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2726737&form=6&db=m 1.14.11.16 675183 Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness J. Hepatol. 44 971-983 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16564107&form=6&db=m 1.14.11.16 673915 Aspartyl-asparagyl beta hydroxylase over-expression in human hepatoma is linked to activation of insulin-like growth factor and notch signaling mechanisms Hepatology 44 446-457 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16871543&form=6&db=m 1.14.11.16 439258 Bovine liver aspartyl beta-hydroxylase. Purification and characterization J. Biol. Chem. 266 14004-14010 1991 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1856229&form=6&db=m 1.14.11.16 659445 Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases J. Biol. Chem. 279 9899-9904 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14701857&form=6&db=m 1.14.11.16 439257 Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase Gene 150 395-399 1994 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7821814&form=6&db=m 1.14.11.16 684228 Ethanol impaired neuronal migration is associated with reduced aspartyl-asparaginyl-beta-hydroxylase expression Acta Neuropathol. 116 303-315 2008 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18478238&form=6&db=m 1.14.11.16 695432 Ethanol inhibition of aspartyl-asparaginyl-beta-hydroxylase in fetal alcohol spectrum disorder: potential link to the impairments in central nervous system neuronal migration Alcohol 43 225-240 2009 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19393862&form=6&db=m 1.14.11.16 675861 Expression of aspartyl beta-hydroxylase and its clinicopathological significance in hepatocellular carcinoma Mod. Pathol. 19 280-286 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16341145&form=6&db=m 1.14.11.16 657901 Factor inhibiting hypoxia-inducible factor (FIH) and other asparaginyl hydroxylases Biochem. Soc. Trans. 32 943-945 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15506931&form=6&db=m 1.14.11.16 687022 Isolation and characterization of human antibodies targeting human aspartyl (asparaginyl) beta-hydroxylase Hum. Antibodies 16 163-176 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18334751&form=6&db=m 1.14.11.16 698201 Monoclonal antibodies against human aspartyl (asparaginyl) beta-hydroxylase developed by DNA immunization Hybridoma 28 251-257 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19663697&form=6&db=m 1.14.11.16 439252 Overexpression of human aspartyl (asparaginyl) beta-hydroxylase is associated with malignant transformation Cancer Res. 60 1261-1266 2000 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10728685&form=6&db=m 1.14.11.16 439254 Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma J. Clin. Invest. 98 1313-1323 1996 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8823296&form=6&db=m 1.14.11.16 698158 Overexpression of insulin receptor substrate-1 and hepatitis Bx genes causes premalignant alterations in the liver Hepatology 49 1935-1943 2009 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19475691&form=6&db=m 1.14.11.16 439259 Partial purification and characterization of bovine liver aspartyl beta-hydroxylase J. Biol. Chem. 265 8558-8565 1990 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2187868&form=6&db=m 1.14.11.16 676817 Posttranslational hydroxylation of ankyrin repeats in IkB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH) Proc. Natl. Acad. Sci. USA 103 14767-14772 2006 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17003112&form=6&db=m 1.14.11.16 698195 Prognostic value of aspartyl (asparaginyl)-beta-hydroxylase/humbug expression in non-small cell lung carcinoma Hum. Pathol. 40 639-644 2009 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19200576&form=6&db=m 1.14.11.16 673951 Role of aspartyl-(asparaginyl) beta-hydroxylase in placental implantation: Relevance to early pregnancy loss Hum. Pathol. 38 50-59 2007 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16949909&form=6&db=m 1.14.11.16 725118 Single-chain variable fragment antibody against human aspartyl/asparaginyl beta-hydroxylase expressed in recombinant Escherichia coli Hybridoma 30 69-79 2011 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21466288&form=6&db=m 1.14.11.16 439255 Site-directed mutagenesis of residues in a conserved region of bovine aspartyl (asparaginyl) beta-hydroxylase: Evidence that histidine 675 has a role in binding Fe2+ Biochemistry 35 3957-3962 1996 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8672427&form=6&db=m 1.14.11.16 659316 Substrate requirements of the oxygen-sensing asparaginyl hydroxylase factor-inhibiting hypoxia-inducible factor J. Biol. Chem. 279 14391-14397 2004 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=14734545&form=6&db=m 1.14.11.16 439253 The five cysteine residues located in the active site region of bovine aspartyl (asparaginyl) beta-hydroxylase are not essential for catalysis Biochim. Biophys. Acta 1387 454-456 1998 Bos taurus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9748662&form=6&db=m