1.1.1.87 746605 De novo biosynthesis of glutarate via alpha-keto acid carbon chain extension and decarboxylation pathway in Escherichia coli ACS Synth. Biol. 6 1922-1930 2017 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28618222&form=6&db=m 1.1.1.87 746605 De novo biosynthesis of glutarate via alpha-keto acid carbon chain extension and decarboxylation pathway in Escherichia coli ACS Synth. Biol. 6 1922-1930 2017 Saccharomyces cerevisiae ATCC 204508 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28618222&form=6&db=m 1.1.1.87 760522 Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J. 474 105-122 2017 Thermococcus kodakarensis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27831491&form=6&db=m 1.1.1.87 760522 Structure and function of an ancestral-type beta-decarboxylating dehydrogenase from Thermococcus kodakarensis Biochem. J. 474 105-122 2017 Thermococcus kodakarensis KUW1 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=27831491&form=6&db=m 1.1.1.87 660907 Bifunctional isocitrate-homoisocitrate dehydrogenase: a missing link in the evolution of beta-decarboxylating dehydrogenase Biochem. Biophys. Res. Commun. 331 341-346 2005 Pyrococcus horikoshii http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=15845397&form=6&db=m 1.1.1.87 656127 Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase J. Biol. Chem. 278 1864-1871 2003 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12427751&form=6&db=m 1.1.1.87 656127 Characterization of homoisocitrate dehydrogenase involved in lysine biosynthesis of an extremely thermophilic bacterium, Thermus thermophilus HB27, and evolutionary implication of beta-decarboxylating dehydrogenase J. Biol. Chem. 278 1864-1871 2003 Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12427751&form=6&db=m 1.1.1.87 685232 Chemical mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae Biochemistry 47 4169-4180 2008 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18321070&form=6&db=m 1.1.1.87 669109 Crystal structure of tetrameric homoisocitrate dehydrogenase from an extreme thermophile, Thermus thermophilus: involvement of hydrophobic dimer-dimer interaction in extremely high thermotolerance J. Bacteriol. 187 6779-6788 2005 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16166541&form=6&db=m 1.1.1.87 687988 Dynamic expression of the retinoic acid-synthesizing enzyme retinol dehydrogenase 10 (rdh10) in the developing mouse brain and sensory organs J. Comp. Neurol. 508 879-892 2008 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18399539&form=6&db=m 1.1.1.87 644543 Enzymatic formation of alpha-ketoadipic acid from homoisocitric acid J. Biol. Chem. 240 4357-4361 1965 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4284830&form=6&db=m 1.1.1.87 739958 Evidence for an induced conformational change in the catalytic mechanism of homoisocitrate dehydrogenase for Saccharomyces cerevisiae: Characterization of the D271N mutant enzyme Arch. Biochem. Biophys. 584 20-27 2015 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=26325079&form=6&db=m 1.1.1.87 722303 Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug FEMS Yeast Res. 13 143-155 2013 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23107040&form=6&db=m 1.1.1.87 722303 Homoisocitrate dehydrogenase from Candida albicans: properties, inhibition, and targeting by an antifungal pro-drug FEMS Yeast Res. 13 143-155 2013 Candida albicans ATCC 10231 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23107040&form=6&db=m 1.1.1.87 644541 Homoisocitric Dehydrogenase Methods Enzymol. 17B 118-119 1971 Saccharomyces cerevisiae - 1.1.1.87 644539 Homoisocitric dehydrogenase from yeast Arch. Biochem. Biophys. 141 499-510 1970 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=4395693&form=6&db=m 1.1.1.87 660918 Identification of a novel trifunctional homoisocitrate dehydrogenase and modulation of the broad substrate specificity through site-directed mutagenesis Biochem. Biophys. Res. Commun. 336 596-602 2005 Deinococcus radiodurans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16139794&form=6&db=m 1.1.1.87 644538 Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans J. Bacteriol. 174 7379-7384 1992 Aspergillus fumigatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429460&form=6&db=m 1.1.1.87 644538 Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans J. Bacteriol. 174 7379-7384 1992 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429460&form=6&db=m 1.1.1.87 644538 Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans J. Bacteriol. 174 7379-7384 1992 Candida albicans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429460&form=6&db=m 1.1.1.87 644538 Lysine biosynthesis in selected pathogenic fungi: characterization of lysine auxotrophs and the cloned LYS1 gene of Candida albicans J. Bacteriol. 174 7379-7384 1992 Cryptococcus neoformans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1429460&form=6&db=m 1.1.1.87 288190 Lysine biosynthesis pathway and biochemical blocks of lysine auxotrophs of Schizosaccharomyces pombe J. Bacteriol. 170 5968-5970 1988 Schizosaccharomyces pombe http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3142867&form=6&db=m 1.1.1.87 696220 Potassium is an activator of homoisocitrate dehydrogenase from Saccharomyces cerevisiae Biochemistry 47 10809-10815 2008 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18785753&form=6&db=m 1.1.1.87 686950 RDH10 is essential for synthesis of embryonic retinoic acid and is required for limb, craniofacial, and organ development Genes Dev. 21 1113-1124 2007 Mus musculus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17473173&form=6&db=m 1.1.1.87 696350 Site-directed mutagenesis as a probe of the acid-base catalytic mechanism of homoisocitrate dehydrogenase from Saccharomyces cerevisiae Biochemistry 48 7305-7312 2009 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19530703&form=6&db=m 1.1.1.87 722569 Structure of Thermus thermophilus homoisocitrate dehydrogenase in complex with a designed inhibitor J. Biochem. 150 607-614 2011 Thermus thermophilus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=21813504&form=6&db=m 1.1.1.87 667934 Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase Bioorg. Med. Chem. 15 1346-1355 2007 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17116397&form=6&db=m 1.1.1.87 667934 Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase Bioorg. Med. Chem. 15 1346-1355 2007 Deinococcus radiodurans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17116397&form=6&db=m 1.1.1.87 685539 Thiahomoisocitrate: a highly potent inhibitor of homoisocitrate dehydrogenase involved in the alpha-aminoadipate pathway Bioorg. Med. Chem. 16 3372-3376 2008 Saccharomyces cerevisiae http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=18086528&form=6&db=m 1.1.1.87 644540 Wild-type and mutant forms of homoisocitric dehydrogenase in the yeast Saccharomycopsis lipolytica Eur. J. Biochem. 128 489-494 1982 Saccharomycopsis lipolytica http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6759120&form=6&db=m