1.1.1.53 763470 Substrate multispecificity among 20?-hydroxysteroid dehydrogenase type 2 members Mol. Cell. Endocrinol. 510 110822 2020 Danio rerio http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=32315721&form=6&db=m 1.1.1.53 762606 Differential expression of subunits of 20?-hydroxysteroid dehydrogenase during gametogenesis in rainbow trout (Oncorhychus mykiss) Anim. Reprod. Sci. 184 139-148 2017 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28735888&form=6&db=m 1.1.1.53 762009 Apigenin inhibits rat neurosteroidogenic 5alpha-reductase 1 and 3alpha-hydroxysteroid dehydrogenase Neurochem. Int. 110 84-90 2017 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28947342&form=6&db=m 1.1.1.53 763346 Identification and characterization of a 20beta-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058 J. Lipid Res. 58 916-925 2017 Agathobaculum desmolans http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314858&form=6&db=m 1.1.1.53 763346 Identification and characterization of a 20beta-HSDH from the anaerobic gut bacterium Butyricicoccus desmolans ATCC 43058 J. Lipid Res. 58 916-925 2017 Agathobaculum desmolans ATCC 43058 http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=28314858&form=6&db=m 1.1.1.53 287108 20beta-Hydroxysteroid dehydrogenase activity in nonflagellated germ cells of rainbow trout testis Biol. Reprod. 54 1-7 1996 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8837993&form=6&db=m 1.1.1.53 287096 The conversion of progesterone to androgens by testes J. Biol. Chem. 232 1015-1030 1958 Cavia porcellus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=13549484&form=6&db=m 1.1.1.53 654932 Ovarian carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase shows distinct surge in messenger RNA expression during natural and gonadotropin-induced meiotic maturation in Nile tilapia Biol. Reprod. 67 1080-1086 2002 Oreochromis niloticus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12297521&form=6&db=m 1.1.1.53 287111 20beta-hydroxysteroid dehydrogenase of the japanes eel ovary: its cellular localization and changes in the enzymatic acitvity during sexual maturation Gen. Comp. Endocrinol. 122 109-115 2001 Anguilla japonica http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11352559&form=6&db=m 1.1.1.53 287086 Multiparameter study of denaturation of 20beta-hydroxysteroid dehydrogenase by urea in the presence of stabilizing agents Biochim. Biophys. Acta 914 122-126 1987 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3475131&form=6&db=m 1.1.1.53 287091 Reduction of steroidal 20-oxo-21-oic acids to steroidal 20-beta-hydroxy-21-oic acids by 20beta-hydroxysteroid dehydrogenase J. Steroid Biochem. 9 1229-1231 1978 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=745420&form=6&db=m 1.1.1.53 687870 Understanding oligomerization in 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: an in silico approach and evidence for an active protein J. Biotechnol. 129 131-139 2007 Comamonas testosteroni http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17258342&form=6&db=m 1.1.1.53 287106 Pig testicular 20beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity J. Biol. Chem. 267 13451-13455 1992 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1377683&form=6&db=m 1.1.1.53 738928 Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): The V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity J. Steroid Biochem. Mol. Biol. 141 135-143 2014 Homo sapiens http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=24434280&form=6&db=m 1.1.1.53 287087 Enzyme-catalyzed steroid transformations in water-organic solvent two-phase systems Methods Enzymol. 136 150-157 1987 Streptomyces exfoliatus - 1.1.1.53 287088 Effect of the lyotropic series of anions on denaturation and renaturation of 20beta-hydroxysteroid dehydrogenase Biochim. Biophys. Acta 784 16-23 1984 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6581837&form=6&db=m 1.1.1.53 287103 Ontogeny of testicular steroid dehydrogenase enzymes in pig (3alpha/beta-, 20alpha- and 20beta-): evidence for two forms of 3alpha/beta-hydroxysteroid dehydrogenase J. Steroid Biochem. Mol. Biol. 42 17-21 1992 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1558817&form=6&db=m 1.1.1.53 287092 Substrate characteristics of progesterone-albumin conjugates with 20beta-hydroxysteroid dehydrogenase Biochem. Biophys. Res. Commun. 83 187-194 1978 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=697807&form=6&db=m 1.1.1.53 725963 Discovery of a novel enzyme mediating glucocorticoid catabolism in fish: 20beta-hydroxysteroid dehydrogenase type 2 Mol. Cell. Endocrinol. 349 202-213 2012 Danio rerio http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=22061621&form=6&db=m 1.1.1.53 287094 20beta-Hydroxysteroid oxidoreductase. Kinetics and binding of corticosteroids and corticosteroid-21-aldehydes J. Biol. Chem. 252 205-211 1977 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=833119&form=6&db=m 1.1.1.53 287102 Further studies on 20beta-hydroxysteroid dehydrogenase with carbonyl reductase-like activity present in liver microsomes of male rats Life Sci. 67 2075-2082 2000 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=11057757&form=6&db=m 1.1.1.53 655669 Cloning of zebrafish ovarian carbonyl reductase-like 20 beta-hydroxysteroid dehydrogenase and characterization of its spatial and temporal expression Gen. Comp. Endocrinol. 127 209-216 2002 Danio rerio http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12225761&form=6&db=m 1.1.1.53 668714 Changes in steroidogenic enzyme and steroidogenic acute regulatory protein messenger RNAs in ovarian follicles during ovarian development of rainbow trout (Oncorhynchus mykiss) Gen. Comp. Endocrinol. 144 224-231 2005 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=16102755&form=6&db=m 1.1.1.53 668684 Expression of 20beta-hydroxysteroid dehydrogenase and P450 17alpha-hydroxylase/c17-20 lyase during hCG-induced in vitro oocyte maturation in snake head murrel Channa striatus Fish Physiol. Biochem. 31 227-230 2006 Gallus gallus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035462&form=6&db=m 1.1.1.53 668684 Expression of 20beta-hydroxysteroid dehydrogenase and P450 17alpha-hydroxylase/c17-20 lyase during hCG-induced in vitro oocyte maturation in snake head murrel Channa striatus Fish Physiol. Biochem. 31 227-230 2006 Channa striata http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=20035462&form=6&db=m 1.1.1.53 287100 Short-chain dehydrogenases. Proteolysis and chemical modification of prokaryotic 3alpha/20beta-hydroxysteroid, insect alcohol and human 15-hydroxyprostaglandin dehydrogenase Eur. J. Biochem. 209 233-239 1992 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1396701&form=6&db=m 1.1.1.53 698084 New evidences for the involvement of 20beta-hydroxysteroid dehydrogenase in final oocyte maturation of air-breathing catfish Gen. Comp. Endocrinol. 163 259-269 2009 Clarias gariepinus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=19401204&form=6&db=m 1.1.1.53 287107 Isoleucine-15 of rainbow trout carbonyl reductase-like 20beta-hydroxysteroid dehydrogenase is critical for coenzyme (NADPH) binding Proc. Natl. Acad. Sci. USA 97 3079-3083 2000 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=10725344&form=6&db=m 1.1.1.53 688455 20 beta-hydroxysteroid dehydrogenase and CYP19A1 are differentially expressed during maturation in Atlantic cod (Gadus morhua) J. Mol. Endocrinol. 39 319-328 2007 Gadus morhua http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17909270&form=6&db=m 1.1.1.53 287104 Involvement of pH in the enhancement of 20beta-hydroxysteroid dehydrogenase activity in isolated granulosa cell layers from ovarian follicles of salmonid fishes Biomed. Res. 11 327-335 1990 Oncorhynchus mykiss - 1.1.1.53 287104 Involvement of pH in the enhancement of 20beta-hydroxysteroid dehydrogenase activity in isolated granulosa cell layers from ovarian follicles of salmonid fishes Biomed. Res. 11 327-335 1990 Oncorhynchus masou rhodurus - 1.1.1.53 686368 Proteomic analyses indicate induction of hepatic carbonyl reductase/20beta-hydroxysteroid dehydrogenase B in rainbow trout exposed to sewage effluent Ecotoxicol. Environ. Safety 68 33-39 2007 Oncorhynchus mykiss http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=17543385&form=6&db=m 1.1.1.53 287093 Comparison of the 3alpha-and 20beta-hydroxysteroid dehydrogenase activities of the cortisone reductase of Streptomyces hydrogenans Biochemistry 17 4370-4376 1978 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=718844&form=6&db=m 1.1.1.53 657157 Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc. Natl. Acad. Sci. USA 100 455-460 2003 Mycobacterium tuberculosis http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524453&form=6&db=m 1.1.1.53 657157 Directed evolution approach to a structural genomics project: Rv2002 from Mycobacterium tuberculosis Proc. Natl. Acad. Sci. USA 100 455-460 2003 Mycobacterium tuberculosis H37Rv http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=12524453&form=6&db=m 1.1.1.53 287085 Properties of immobilized subunits of 20beta-hydroxysteroid dehydrogenase Methods Enzymol. 135 475-483 1987 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3474489&form=6&db=m 1.1.1.53 287089 Study of 3alpha, 20beta-hydroxysteroid dehydrogenase with an enzyme-generated affinity alkylator: dual enzyme activity at a single active site Biochemistry 19 4950-4954 1980 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6936053&form=6&db=m 1.1.1.53 287101 20beta-Hydroxysteroid dehydrogenase catalyzes ketone-reduction of acetohexamide, an oral antidiabetic drug, in liver microsomes of adult male rats J. Pharmacol. Exp. Ther. 287 504-507 1998 Rattus norvegicus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9808673&form=6&db=m 1.1.1.53 287084 20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: purification and some properties J. Biochem. 104 565-569 1988 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=3240999&form=6&db=m 1.1.1.53 287099 The molecular weight and substrate specificity of 20beta-hydroxysteroid dehydrogenase from Streptomyces hydrogenans Arch. Biochem. Biophys. 159 590-595 1973 Streptomyces exfoliatus - 1.1.1.53 287110 The refined three-dimensional structure of 3alpha,20beta-hydroxysteroid dehydrogenase and possible roles of the residues conserved in short-chain dehydrogenases Structure 2 629-640 1994 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7922040&form=6&db=m 1.1.1.53 287097 20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: 3alpha/beta-hydroxysteroid dehydrogenase activities catalyzed by highly purified enzyme J. Steroid Biochem. Mol. Biol. 38 787-794 1991 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2064995&form=6&db=m 1.1.1.53 287083 Enzyme kinetics in reversed micelles. 3. Behaviour of 20beta-hydroxysteroid dehydrogenase Eur. J. Biochem. 187 81-88 1990 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=2298212&form=6&db=m 1.1.1.53 287095 20beta-hydroxy-steroid-dehydrogenase II. Darstellung und Kristallisation Biochem. Z. 333 95-105 1960 Streptomyces exfoliatus - 1.1.1.53 287098 20beta-Hydroxysteroid dehydrogenase of neonatal pig testis: reverse catalytic (oxidation) reaction Chem. Pharm. Bull. 39 972-975 1991 Sus scrofa http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=1893501&form=6&db=m 1.1.1.53 287109 Mechanism of inhibition of 3alpha, 20beta-hydroxysteroid dehydrogenase by a licorice-derived steroidal inhibitor Curr. Biol. 2 973-980 1994 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=7866748&form=6&db=m 1.1.1.53 287090 Bifunctional enzyme activity at the same active site: study of 3alpha and 20beta activity by affinity alkylation of 3alpha, 20beta-hydroxysteroid dehydrogenase with 17-(bromoacetoxy)steroids Biochemistry 19 978-986 1980 Streptomyces exfoliatus http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=6928375&form=6&db=m 1.1.1.53 726321 Zebrafish 20beta-hydroxysteroid dehydrogenase type 2 is important for glucocorticoid catabolism in stress response PLoS ONE 8 e54851 2013 Danio rerio http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=23349977&form=6&db=m