3.6.4.6 ATP + H2O = ADP + phosphate large family of ATP-hydrolysing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. They include peroxin, which apparently is involved in Zellweger 's syndrome. 210576, 210577, 210578, 210579, 210580, 210581, 210582, 210583, 210584, 210585, 210586 3.6.4.6 ATP + H2O = ADP + phosphate Vps4 disassembles the ESCRT-III protein polymer, thereby changing the morphology of the underlying membrane 724447